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Not all 2’,4’-bridged modifications stabilize DNA/RNA duplexes
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.3 ) Pub Date : 2023-07-09 , DOI: 10.1080/15257770.2023.2232414 Tomoka Akita 1, 2 , Elisa Tomita-Sudo 2 , Shin Itoh 1 , Nae Sakimoto 2 , Takeshi Masuda 3 , Akifumi Nakamura 3 , Yoshiyuki Onishi 3 , Makoto Koizumi 3 , Junji Kawakami 1, 2
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.3 ) Pub Date : 2023-07-09 , DOI: 10.1080/15257770.2023.2232414 Tomoka Akita 1, 2 , Elisa Tomita-Sudo 2 , Shin Itoh 1 , Nae Sakimoto 2 , Takeshi Masuda 3 , Akifumi Nakamura 3 , Yoshiyuki Onishi 3 , Makoto Koizumi 3 , Junji Kawakami 1, 2
Affiliation
2’,4’-Bridged modifications such as 2’-O,4’-C-methylene-bridged nucleotides (LNAs) and 2’-O,4’-C-ethylene-bridged nucleotides (ENAs) provide high binding affinity for duplex formation. Stabilizatio...
中文翻译：
并非所有 2',4'-桥接修饰都能稳定 DNA/RNA 双链体
2',4'-桥接修饰，例如 2'-O,4'-C-亚甲基桥接核苷酸 (LNA) 和 2'-O,4'-C-亚乙基桥接核苷酸 (ENA) 提供高结合亲和力双链体形成。稳定化...
更新日期：2023-07-09
中文翻译：
并非所有 2',4'-桥接修饰都能稳定 DNA/RNA 双链体
2',4'-桥接修饰，例如 2'-O,4'-C-亚甲基桥接核苷酸 (LNA) 和 2'-O,4'-C-亚乙基桥接核苷酸 (ENA) 提供高结合亲和力双链体形成。稳定化...
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