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A pharmacokinetic study of extended-release buprenorphine in cynomolgus monkeys (Macaca fasicularis)
Journal of Medical Primatology ( IF 0.7 ) Pub Date : 2023-07-11 , DOI: 10.1111/jmp.12661
Hilton Klein 1 , Barry L Levinson 2 , Steven L Leary 2 , Glenn Dobson 3
Affiliation  

A novel buprenorphine (BUP) extended-release formulation (BUP-XR) produced as a lipid-encapsulated, low viscosity BUP suspension for subcutaneous (SC) injection to control pain was evaluated for pharmacokinetics and safety in four adult male cynomolgus monkeys.

中文翻译:

缓释丁丙诺啡在食蟹猴(Macaca fasularis)体内的药代动力学研究

在四只成年雄性食蟹猴中评估了一种新型丁丙诺啡 (BUP) 缓释制剂 (BUP-XR) 的药代动力学和安全性,该制剂是一种脂质封装的低粘度 BUP 混悬液,用于皮下 (SC) 注射以控制疼痛。
更新日期:2023-07-11
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