Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.

长链非编码RNA（lncRNA）在多种癌症的发生和进展中发挥着至关重要的调节作用。然而，lncRNA影响卵巢癌复发和转移的潜在机制仍不清楚。在目前的研究中，与原发性肿瘤相比，lncRNA LOC646029在转移性卵巢肿瘤中显着下调。功能获得和丧失检测表明 LOC646029在体内和体外抑制卵巢癌细胞的增殖、侵袭和转移。此外，转移性卵巢肿瘤中LOC646029的下调与不良预后密切相关。从机制上讲，LOC646029 作为 miR-627-3p 海绵，促进 Sprouty 相关 EVH1 结构域蛋白 1 的表达，这对于抑制肿瘤转移和抑制 KRAS 信号传导是必需的。总的来说，我们的结果表明 LOC646029 参与卵巢癌的进展和转移，这可能是潜在的预后生物标志物。