Objective: Cases of cow's milk allergy (CMA) who reacted to measles or measles, mumps, and rubella (MMR) vaccines containing alpha-lactalbumin have been reported. The purpose of this study was to assess patients with CMA who received measles or MMR vaccines containing alpha-lactalbumin, as well as the characteristics of those who developed reactions to these vaccines. Study Design: Patients followed up in the allergy clinic for CMA and who received measles or MMR vaccines containing alpha-lactalbumin at 9 or 12 months of age were included in the study, and their characteristics were analyzed retrospectively from the hospital registry system. Results: Forty-nine patients were included in the study. Six patients received the measles vaccine, whereas 43 patients received the MMR vaccine containing alpha-lactalbumin. Vaccine skin tests were performed on these 6 patients. One patient had a positive intradermal test, so an alternative vaccine not containing alpha-lactalbumin was administered. The other 5 patients were vaccinated, and no reaction was observed. Anaphylaxis was observed in 3 of 43 patients who received the MMR vaccine containing alpha-lactalbumin. In all of these patients, the first reaction to dairy products was anaphylaxis. In 2 of those patients, cow's milk-specific IgE (spIgE) levels were >100 kU/L, and alpha-lactalbumin-spIgE levels were also high at 97 and 90 kU/L. The third patient's cow's milk-spIgE level was 15.9 kU/L, whereas the alpha-lactalbumin-spIgE level was 0.04 kU/L. Conclusion: Especially in patients with an initial reaction of anaphylaxis to dairy products and high cow's milk-spIgE levels, the risk of reaction is high with the MMR vaccine.

中文翻译：

---

对接受过麻疹或含有α-乳清蛋白的麻疹、腮腺炎和风疹疫苗的牛奶过敏儿童的评估。

目的：已有对含有 α-乳清蛋白的麻疹或麻疹、腮腺炎和风疹 (MMR) 疫苗产生反应的牛奶过敏 (CMA) 病例的报告。本研究的目的是评估接受过麻疹或含有 α-乳清蛋白的 MMR 疫苗的 CMA 患者，以及对这些疫苗产生反应的患者的特征。研究设计：在过敏诊所进行 CMA 随访并在 9 或 12 个月大时接受过麻疹或含有 α-乳白蛋白的 MMR 疫苗的患者被纳入研究，并通过医院登记系统对他们的特征进行回顾性分析。结果：49 名患者被纳入研究。6 名患者接种了麻疹疫苗，43 名患者接种了含有 α-乳白蛋白的 MMR 疫苗。对这6名患者进行了疫苗皮试。一名患者的皮内测试呈阳性，因此注射了不含 α-乳白蛋白的替代疫苗。另外5名患者接种了疫苗，未观察到反应。在接受含有 α-乳清蛋白的 MMR 疫苗的 43 名患者中，有 3 名患者出现过敏反应。在所有这些患者中，对乳制品的第一反应是过敏反应。其中 2 名患者的牛奶特异性 IgE (spIgE) 水平 >100 kU/L，α-乳清蛋白-spIgE 水平也很高，分别为 97 和 90 kU/L。第三位患者的牛奶-spIgE 水平为15.9 kU/L，而α-乳清蛋白-spIgE 水平为0.04 kU/L。结论：特别是对于初次对乳制品产生过敏反应且牛奶 spIgE 水平较高的患者，接种 MMR 疫苗后出现过敏反应的风险较高。