Background Videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) are part of the diagnostic and therapeutic work-up of indications other than suspected small bowel bleeding (OSBB). The literature is currently lacking studies describing these procedures in this particular setting. Objectives We assessed the clinical impact of VCE and DBE in a large monocentric cohort of OSBB patients, as compared to a control group of suspected small bowel bleeding (SSBB) patients who underwent enteroscopy over the same period. Design Monocentric, retrospective, cohort study. Methods We collected the data of consecutive patients with OSBB undergoing VCE and/or DBE from March 2001 to July 2020. The demographic and clinical parameters of the patients, technical characteristics, and adverse events for each procedure were collected. The impact of VCE and DBE was defined in terms of diagnostic yield (DY). The patients were subdivided according to the main indication into four groups: celiac disease, Crohn's disease (CD), neoplasia, and persistent gastrointestinal symptoms. Results A total of 611 VCEs and 387 DBEs were performed for OSBB. The main indications were complicated celiac disease and CD. The DYs of VCE and DBE overall were 53 and 61.7%, respectively, with some variance among the four groups. We report no statistical differences in the DY of VCE and DBE in SSBB vs OSBB (57.7% vs 53%, p = 0.0859 and 68.8% vs 61.7%, p = 0.0582, respectively). OSBB patients were significantly younger than those with SSBB. However, similarly to SSBB (k = 0.059), poor agreement between the enteroscopic techniques was found in the OSBB population (k = 0.109). The safety of both procedures in OSBB was comparable to that in SSBB patients. Conclusion VCE and DBE are effective and safe in suspected OSBB, where their role is similar to that in SSBB, their main indication.

中文翻译：

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视频胶囊内窥镜和设备辅助肠镜检查对非出血性小肠病变的临床影响。

背景视频胶囊内窥镜（VCE）和双气囊小肠镜（DBE）是疑似小肠出血（OSBB）以外适应症的诊断和治疗检查的一部分。目前文献缺乏描述这种特定环境下这些程序的研究。目的 我们评估了 VCE 和 DBE 在大型单中心 OSBB 患者队列中的临床影响，并与同期接受肠镜检查的疑似小肠出血 (SSBB) 患者的对照组进行比较。设计单中心、回顾性、队列研究。方法我们收集了2001年3月至2020年7月连续接受VCE和/或DBE的OSBB患者的数据。收集患者的人口统计学和临床​​参数、技术特征以及每次手术的不良事件。VCE 和 DBE 的影响根据诊断率 (DY) 来定义。根据主要适应症将患者分为四组：乳糜泻、克罗恩病（CD）、肿瘤和持续性胃肠道症状。结果 OSBB 共进行了 611 次 VCE 和 387 次 DBE。主要适应症是复杂性乳糜泻和CD。VCE 和 DBE 总体 DY 分别为 53 和 61.7%，四组之间存在一定差异。我们报告 SSBB 与 OSBB 的 VCE 和 DBE DY 没有统计差异（分别为 57.7% vs 53%，p = 0.0859 和 68.8% vs 61.7%，p = 0.0582）。OSBB 患者明显比 SSBB 患者年轻。然而，与 SSBB (k = 0.059) 类似，OSBB 人群 (k = 0.109) 中肠镜技术之间的一致性较差。OSBB 患者中两种手术的安全性与 SSBB 患者相当。结论 VCE和DBE对疑似OSBB有效且安全，其作用与其主要适应症SSBB相似。