In the 19th century, psychiatric genetic studies typically utilized a generic category of “insanity.” This began to change after 1899, with the publication of Kraepelin's 6th edition containing, among other disorders, his mature concept of dementia praecox (DP). We here review an article published by Ryssia Wolfsohn in 1907 from her dissertation at the University of Zurich entitled “Die Heredität bei Dementia praecox” (The Heredity of Dementia Praecox). This work, performed under the supervision of E. Bleuler, was to our knowledge the first formal genetic study of the then new diagnosis of DP. She investigated 550 DP probands admitted to the Burghölzli hospital with known information about their “heredity burden.” For most probands, she had information on parents, siblings, grandparents, and aunts/uncles. Of these patients, only 10% had no psychiatric illness in their families. In the remaining probands, she found rates of the four major categories of psychopathology she investigated: mental illness—56%, nervous disorders—19%, peculiar personalities 12% and alcoholism 13%. Her most novel analyses compared either total familial burden or burden of her four forms of mental disorders on her DP probands divided by subtype and outcome. In neither of these analyses, did she find significant differences.

中文翻译：

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Ryssia Wolfsohn 1907 年的论文“早发性痴呆的遗传”

在 19 世纪，精神病学遗传学研究通常使用“精神错乱”这一通用类别。 1899 年之后，随着克雷佩林第六版的出版，这种情况开始发生变化，其中包括他对早发性痴呆 (DP) 的成熟概念。我们在此回顾 Ryssia Wolfsohn 于 1907 年在苏黎世大学发表的一篇论文，题为“Die Heredität bei Dementia praecox”（早发痴呆的遗传）。这项工作是在 E. Bleuler 的监督下进行的，据我们所知，这是对当时新诊断的 DP 的第一个正式的遗传学研究。她调查了 Burghölzli 医院收治的 550 名 DP 先证者，了解他们“遗传负担”的已知信息。对于大多数先证者，她有关于父母、兄弟姐妹、祖父母和阿姨/叔叔的信息。在这些患者中，只有10%的人家人没有精神疾病。在剩下的先证者中，她发现了她所研究的四种主要精神病理学类别的比率：精神疾病——56%，神经障碍——19%，特殊性格12%，酗酒13%。她最新颖的分析比较了 DP 先证者的总家庭负担或四种形式的精神障碍负担，并按亚型和结果划分。在这两项分析中，她都没有发现显着差异。