The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis.

前 mRNA 的忠实剪接对于基因的准确表达至关重要。mRNA 前体剪接的失调与包括癌症在内的多种人类疾病有关。类泛素蛋白 Hub1/UBL5 以非共价方式与底物结合并促进前 mRNA 剪接。此外，UBL5 还可促进常见脆弱位点的稳定性和 DNA 损伤修复的范可尼贫血途径。这些功能强烈表明 UBL5 可能与癌症有关。因此，我们分析了TCGA肿瘤样本数据集中的UBL5表达，观察不同肿瘤亚型之间肿瘤和正常组织之间的差异。我们注意到 TCGA 肿瘤样本中 UBL5 的改变频率。总之，这篇综述总结了 UBL5 的功能并讨论了其在肿瘤发生中的假定作用。