Aim. The present study aimed at investigating associations of the platelet-to-monocyte ratio (PMR), a novel hematological indicator of inflammatory responses with 30-day outcomes in patients with HBV-associated decompensated cirrhosis (HBV-DeCi). Methods. We recruited 329 patients with HBV-DeCi for this retrospective study and extracted baseline clinical data and laboratory characteristics from medical records. Univariate and multivariate analyses were performed to determine major factors influencing 30-day mortality. Receiver operating characteristic curve analysis was performed to compare the predictive values of prognostic markers. Results. During the 30-day follow-up period, 21 (6.4%) patients died. The PMR was significantly different between nonsurvivors and survivors. Lower PMR was found to be associated with an increased risk of 30-day mortality, and PMR (odds ratio: 1.011; 95% CI: 1.003–1.019; ) was found to be an independent predictor of 30-day mortality in patients with HBV-DeCi with a significant predictive value (AUC = 0.826, 95% CI: 0.781–0.865). The combination of PMR and MELD score could improve prognostic accuracy in these patients (AUC = 0.911, 95% CI: 0.876–0.940). Conclusions. Our results demonstrate that low PMR may be an independent predictor of 30-day mortality in patients with HBV-DeCi, and combined with the MELD score, it may be useful to complement other conventional measures to enable effective management of these patients.

中文翻译：

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血小板与单核细胞比率作为乙型肝炎病毒相关失代偿性肝硬化预后的新型有前景药物

目的。本研究旨在调查血小板与单核细胞比率 (PMR)（一种新的炎症反应血液学指标）与 HBV 相关失代偿性肝硬化 (HBV-DeCi) 患者 30 天预后的关系。方法。我们招募了 329 名 HBV-DeCi 患者进行这项回顾性研究，并从病历中提取基线临床数据和实验室特征。进行单变量和多变量分析以确定影响 30 天死亡率的主要因素。进行受试者工作特征曲线分析以比较预后标志物的预测值。结果。在 30 天的随访期间，21 名患者（6.4%）死亡。非幸存者和幸存者之间的 PMR 存在显着差异。研究发现，较低的 PMR 与 30 天死亡率和 PMR 的风险增加相关（比值比：1.011；95% CI：1.003–1.019；）被发现是 HBV-DeCi 患者 30 天死亡率的独立预测因子，具有显着的预测价值（AUC = 0.826，95% CI：0.781-0.865）。PMR 和 MELD 评分相结合可以提高这些患者的预后准确性（AUC = 0.911，95% CI：0.876-0.940）。结论。我们的结果表明，低 PMR 可能是 HBV-DeCi 患者 30 天死亡率的独立预测因素，并且与 MELD 评分相结合，可能有助于补充其他常规措施，以实现对这些患者的有效管理。