Carbon nanomaterials are widely used in biomedical applications due to their versatile properties. These are the attractive candidates for the carrying of anticancer drugs, genes, and proteins for chemotherapy. Imatinib is an effective chemotherapy drug whose toxicity has created a significant limitation in treatment. In this research, a new biocompatible nanocarrier based on albumin-magnetite graphene oxide conjugates was reported for the loading and release of imatinib. The magnetite graphene oxide nanocomposite was investigated by ultra violet-visible spectroscopy (UV-Vis), field emission scanning electron microscope (FE-SEM), X-ray diffraction spectroscopy (XRD) and energy diepersive X-ray spectroscopy (EDX) methods. The crystallite size of Fe₃O₄ nanoparticles on graphene oxide obtained from XRD is about 14 nm which is in agreement well with the SEM results. We show that magnetite graphene oxide conjugated with albumin is an extremely efficient carrier. An efficient loading of IM, 81% at pH 7.0, time 2 h and initial concentration of 1 mg/mL was seen onto magnetite graphene oxide-albumin in comparison to graphene oxide and magnetite graphene oxide due to the presence of oxygen and nitrogen functional groups of albumin. Upon the pH 9.0 and 7.0, 7% and 16% imatinib could be released from the magnetite graphene oxide-albumin in a time span of 5 h but when exposed pH 4.0 the corresponding 31% was released in 5 h. After 20 h, 21, 42 and 68% of imatinib was released at pH 9.0, 7.0 and 4.0, respectively. This illustrates the major benefits of the developed approach for biomedical applications.

Graphical Abstract

中文翻译：

---

磁铁矿氧化石墨烯-白蛋白缀合物：伊马替尼抗癌药物的载体

碳纳米材料由于其多功能特性而广泛应用于生物医学应用。这些是携带用于化疗的抗癌药物、基因和蛋白质的有吸引力的候选者。伊马替尼是一种有效的化疗药物，其毒性对治疗造成了很大的限制。在这项研究中，报道了一种基于白蛋白-磁铁矿氧化石墨烯缀合物的新型生物相容性纳米载体，用于伊马替尼的负载和释放。通过紫外可见光谱（UV-Vis）、场发射扫描电子显微镜（FE-SEM）、X射线衍射光谱（XRD）和能量二色散X射线光谱（EDX）方法对磁铁矿氧化石墨烯纳米复合材料进行了研究。_{从XRD获得的氧化石墨烯上的Fe 3} O ₄纳米颗粒的晶粒尺寸约为14 nm，这与SEM结果非常吻合。我们证明与白蛋白缀合的磁铁矿氧化石墨烯是一种极其有效的载体。由于氧和氮官能团的存在，与氧化石墨烯和磁铁矿氧化石墨烯相比，在 pH 7.0、时间 2 小时和初始浓度 1 mg/mL 下，IM 的有效负载量为 81%。白蛋白。在 pH 9.0 和 7.0 时，磁铁矿氧化石墨烯-白蛋白可在 5 小时内释放出 7% 和 16% 伊马替尼，但当暴露于 pH 4.0 时，相应的 31% 在 5 小时内释放。20小时后，pH 9.0、7.0和4.0时分别释放21%、42%和68%的伊马替尼。这说明了所开发的生物医学应用方法的主要优点。

图形概要