Chronic kidney disease (CKD) is a group of chronic diseases caused by kidney damage from multiple causes. Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. Based on longitudinal data analysis of the association between estimated glomerular filtration rate (eGFR), proteinuria and MS in patients with CKD, this study aims to provide new ideas for the pathophysiological mechanism of CKD and a theoretical basis for the early prevention and effective intervention of MS-related kidney damage. A total of 126 patients with CKD were divided into non-MS group and MS group. According to the eGFR level, 126 patients with CKD were divided into G1 group, G2 group, G3a group, G3b group, G4 group and G5 group. Serum markers such as eGFR, urine protein, and triglycerides (TG) were collected. The correlation between eGFR, urine protein and MS-related indexes was analysed, and the risk factors affecting CKD complicated by MS were analysed. In patients with CKD, the levels of urine protein, abdominal circumference, TG, systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FPG) were increased with the course of the disease, but the levels of eGFR and high density lipoprotein (HDL-C) were decreased (p < 0.05). Abdominal circumference, TG, SBP, DBP, FP were significantly negatively correlated with eGFR, but HDL-C was positively correlated with eGFR (p < 0.05). Diabetes, hyperlipidemia, UA, and SBP were independent risk factors affecting CKD complicated MS, and eGFR were independent protective factors (p < 0.05). The combination of diabetes, hyperlipidemia, UA, SBP, and eGFR exhibited higher prediction value for the CKD patients complicated by MS. There was a certain correlation between between MS components with eGFR and urinary protein in patients with CKD. The early intervention treatment of MS was helpful in delaying the development of CKD and reducing proteinuria.

中文翻译：

---

基于纵向数据分析慢性肾病患者肾小球滤过率、蛋白尿与代谢综合征之间的关系。

慢性肾脏病（CKD）是一组多种原因导致肾脏损害的慢性疾病。代谢综合征（MS）表现为内皮细胞功能障碍和慢性功能性炎症状态，并可能参与肾功能损害相关的病理改变。本研究基于对CKD患者估计肾小球滤过率（eGFR）、蛋白尿与MS之间关系的纵向数据分析，旨在为CKD的病理生理机制提供新思路，并为CKD的早期预防和有效干预提供理论依据。 MS 相关的肾脏损害。共有126例CKD患者分为非MS组和MS组。根据eGFR水平，将126例CKD患者分为G1组、G2组、G3a组、G3b组、G4组和G5组。收集血清标志物，如 eGFR、尿蛋白和甘油三酯 (TG)。分析eGFR、尿蛋白与MS相关指标的相关性，分析影响CKD并发MS的危险因素。CKD患者的尿蛋白、腹围、TG、收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）水平随病程延长而升高，但eGFR 和高密度脂蛋白 (HDL-C) 降低 (p < 0.05)。腹围、TG、SBP、DBP、FP 与 eGFR 呈显着负相关，但 HDL-C 与 eGFR 呈正相关（p < 0.05）。糖尿病、高脂血症、UA、SBP是影响CKD并发MS的独立危险因素，eGFR是独立保护因素（p < 0.05）。糖尿病、高脂血症、UA、SBP、eGFR联合对CKD并发MS患者表现出较高的预测价值。CKD患者的MS成分与eGFR和尿蛋白之间存在一定的相关性。MS的早期干预治疗有助于延缓CKD的发展、减少蛋白尿。