Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

溶致非层状液晶（LLC）纳米自组装体（包括立方体和六糖体）是用于药物和营养分子的封装和递送的有吸引力的多功能平台。这是由于它们独特的结构特征和结构排列可以高效地负载具有不同物理化学性质的小分子和大分子。考虑到已报道的长链 omega-3 多不饱和脂肪酸（ω -3 PUFA）及其前体ω -3 PUFA 单酰基甘油的健康促进作用；在这里，我们重点关注由磷脂酰甘油和三种类型的ω的二元混合物组装而成的新非层状 LLC 纳米颗粒家族的物理化学和生物特性-3 PUFA，或来自单一ω -3 PUFA 单酰基甘油。我们讨论了在了解其复杂性、pH 敏感性和结构可调性方面的最新进展，并强调了它们在健康和医学方面的潜在应用。