Thrombotic accumulation is associated with surface interactions between blood proteins and vascular access devices. Catheter occlusion results from this process, and is a costly, common, occurrence with peripherally inserted central catheters (PICCs). Hydrophilic catheter materials exhibit antithrombotic properties. This retrospective study evaluates the occurrence of catheter occlusion of PICCs constructed of a poly(vinyl alcohol)-based hydrogel composite known as hydrophilic biomaterial (HBM), compared to thermoplastic polyurethane (TPU) control devices. A total of 121 PICCs, 60 HBM and 61 TPU, were placed in patients with a clinical need and were reviewed for the occurrence of catheter occlusion. The records review found that occlusions occurred in 0/60 (0.0%) of the HBM PICCs and 13/61 (21.3%) of TPU PICCs (p = 0.001). HBM exhibits favorable qualities for vascular access, most importantly its extreme hydrophilicity. Clinically, this may be responsible for the reduction in PICC occlusions, which could improve patient outcomes.

Graphical Abstract

中文翻译：

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聚乙烯醇基水凝胶复合材料经外周插入中心导管闭塞率的回顾性比较临床研究

血栓积聚与血液蛋白和血管通路装置之间的表面相互作用有关。导管闭塞是这一过程的结果，对于经外周插入中心静脉导管 (PICC) 来说，这是一种成本高昂且常见的现象。亲水性导管材料表现出抗血栓特性。这项回顾性研究评估了与热塑性聚氨酯 (TPU) 控制装置相比，由聚乙烯醇基水凝胶复合材料（称为亲水生物材料 (HBM)）构成的 PICC 导管闭塞的发生率。共有121个PICC、60个HBM和61个TPU被放置在有临床需要的患者体内，并检查是否发生导管闭塞。记录审查发现，0/60 (0.0%) 的 HBM PICC 和 13/61 (21.3%) 的 TPU PICC 发生闭塞 ( p  = 0.001)。HBM 具有良好的血管通路特性，最重要的是其极高的亲水性。临床上，这可能是减少 PICC 闭塞的原因，从而改善患者的预后。

图形概要