Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) refers to those MTLE patients who have neither magnetic resonance imaging (MRI) lesions nor definite pathological evidence of hippocampal sclerosis. They usually have resistance to antiepileptic drugs, difficulties in precise seizure location and poor surgical outcomes. Adenosine is a neuroprotective neuromodulator that acts as a seizure terminator in the brain. The role of adenosine in no-HS MTLE is still unclear. Further research to explore the aetiology and pathogenesis of no-HS MTLE may help to find new therapeutic targets.

中文翻译：

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神经元腺苷激酶的异位表达，一种无海马硬化的内侧颞叶癫痫的生物标志物

无海马硬化的内侧颞叶癫痫（no-HS MTLE）是指既没有磁共振成像（MRI）病变，也没有明确的海马硬化病理证据的MTLE患者。他们通常对抗癫痫药物有抵抗力，难以精确定位癫痫发作，且手术效果不佳。腺苷是一种神经保护性神经调节剂，可作为大脑中的癫痫发作终止剂。腺苷在 no-HS MTLE 中的作用仍不清楚。进一步研究探索 no-HS MTLE 的病因和发病机制可能有助于寻找新的治疗靶点。