The thiazole derivatives as important members of heterocyclic compounds have attracted much synthetic interest due to their different biological properties. In recent years, studies on the syn-thesis of morpholine compounds have increased because of the properties of this core. In particular, the hybrid structures in which the thiazole ring is linked to morpholine nuclei in one molecular frame have gained popularity. The presented review is an attempt to summarize a huge volume of data on morpholinothiazoles being a widely studied class of these molecules used in modern organic and me-dicinal chemistry. The manuscript covers the approaches to the synthesis of the morpholinothiazoles derivatives. The synthetic strategies of the target compounds depend on one-pot or multistage reac-tions or the transformation of other related heterocycles. Additionally, we covered the biological ac-tivities and other applications of certain morpholinothiazoles. The information on these compounds made special consideration of medicinal chemists to yield a combinatorial library and carry out thor-ough efforts in the search of morpholinothiazoles.

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功能化吗啉-噻唑支架：合成策略及应用

噻唑衍生物作为杂环化合物的重要成员，由于其不同的生物学特性而引起了人们的广泛关注。近年来，由于该核的特性，吗啉化合物的合成研究不断增加。特别是，噻唑环与吗啉核连接在一个分子框架中的杂化结构已受到欢迎。本文试图总结关于吗啉噻唑的大量数据，吗啉噻唑是现代有机和药物化学中广泛研究的一类分子。该手稿涵盖了吗啉噻唑衍生物的合成方法。目标化合物的合成策略取决于一锅或多级反应或其他相关杂环的转化。此外，我们还介绍了某些吗啉噻唑的生物活性和其他应用。药物化学家特别考虑了这些化合物的信息，建立了一个组合库，并在吗啉噻唑的搜索中进行了彻底的努力。