Both pet and research pigs can suffer from some degree of pain from surgery, injuries, or osteoarthritis (OA). Despite this, there is a paucity of data on safe and effective analgesia agents in pigs. Grapiprant is an EP4 antagonist that blocks the action of the pro-inflammatory prostanoid, PGE₂. It has shown efficacy in attenuating pain associated with ovariohysterectomy and OA in dogs. However, there are no data regarding grapiprant in pigs. Therefore, the pharmacokinetic profile of orally administered grapiprant to juvenile pigs (Sus scrofa domestica) was evaluated in this study. Seven juvenile pigs received 12 mg/kg grapiprant orally. Blood was collected from an indwelling jugular catheter using the push–pull method at set timepoints up to 48 hours. Sample analysis was performed with high-performance liquid chromatography. Mean grapiprant plasma concentration was 164.3 ± 104.7 ng/mL which occurred at 0.8 ± 0.3 h. This study demonstrated that grapiprant concentrations consistent with analgesia in dogs were reached at this dosage in pigs. Further studies are needed to evaluate the efficacy of grapiprant in pigs.

中文翻译：

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单次口服剂量 grapiprant 在幼猪 (Sus scrofa Domestica) 中的药代动力学

宠物猪和研究猪都会因手术、受伤或骨关节炎 (OA) 而遭受某种程度的疼痛。尽管如此，关于猪用安全有效的镇痛剂的数据仍然很少。Grapiprant 是一种 EP4 拮抗剂，可阻断促炎性前列腺素类 PGE ₂的作用。它已显示出可以减轻狗卵巢子宫切除术和 OA 相关疼痛的功效。然而，没有关于猪的 gripiprant 的数据。因此，本研究评估了幼猪（ Sus scrofa Domestica ）口服Grapiprant的药代动力学特征。7 头幼猪口服 12 mg/kg gripiprant。使用推拉法在长达 48 小时的设定时间点从留置颈静脉导管采集血液。采用高效液相色谱法进行样品分析。0.8 ± 0.3 小时时的平均 grapiprant 血浆浓度为 164.3 ± 104.7 ng/mL。这项研究表明，在猪身上使用该剂量时，Grapiprant 的浓度与狗的镇痛效果一致。需要进一步的研究来评估 gripiprant 对猪的功效。