ABSTRACT

Most xanthan gum-based hydrogels are crosslinked by physical methods, but they typically have inadequate mechanical strength and low thermal, pH, and salt stability. To improve the physicochemical properties of XG-based hydrogels, this study applied periodate oxidation of XG to produce ring-opened products with dialdehyde groups for forming chemically crosslinked hydrogels. The research investigated the effects of oxidized xanthan gum (OXG) at different degrees on the properties of its hydrogels with N,O-carboxymethyl chitosan (NOCC), a water-soluble chitosan derivative. Results show that the rigidity and brittleness of NOCC/OXG hydrogels were enhanced with the increased oxidation of XG. Additionally, the swelling ratio of NOCC/OXG hydrogels was increased by 3.5 times and the degradation rate was reduced by 1.5 times. These hydrogels are promising biomaterials for drug delivery, cell therapy, or tissue regeneration applications.

摘要

大多数黄原胶基水凝胶是通过物理方法交联的，但它们通常机械强度不足，且热稳定性、pH 值和盐稳定性较低。为了改善XG基水凝胶的理化性质，本研究应用XG的高碘酸盐氧化来产生具有二醛基团的开环产物，从而形成化学交联的水凝胶。该研究研究了不同程度的氧化黄原胶（OXG）对其与水溶性壳聚糖衍生物N,O-羧甲基壳聚糖（NOCC）水凝胶性能的影响。结果表明，NOCC/OXG 水凝胶的刚性和脆性随着 XG 氧化的增加而增强。此外，NOCC/OXG水凝胶的溶胀比提高了3.5倍，降解率降低了1.5倍。