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Climate change: approach to intervention using expression vector for carbonic anhydrase via glycosylphosphatidylinositol
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.3 ) Pub Date : 2023-07-27 , DOI: 10.1080/15257770.2023.2238781
Zhang Huili 1 , Kefeng Li 2 , Khue Vu Nguyen 1
Affiliation  

Abstract

Climate change is a change in the usual weather found in a place. The climate change has a major impact not only on natural disasters of the Earth but also on human health. The climate crisis is then no longer a future concern. It includes both the global warming driven by human emissions of greenhouse gases (GHG), and the resulting large-scale shifts in weather patterns. Global warming can occur from a variety of causes, both natural and human induced. The primary GHG in Earth’s atmosphere, listed in decreasing order of average global mole fraction, are: water vapor (H2O), carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), and ozone (O3). Today, scientists around the world continue to try and solve the puzzle of climate change. It is clear that to address climate change, the amount of CO2 released into the atmosphere by industrial process has to be reduced because once it is added to the atmosphere, it can continue to affect climate for thousands of years. For such a purpose, an approach to intervention using expression vectors for any protein targeting to the cell plasma membrane via the glycosylphosphatidylinositol, GPI, anchor is suggested. The resulting GPI-anchored proteins would be useful for studying intermolecular interactions, especially gene-environment interactions, in investigating the potential impact of any chemical compounds on any genes of interest and could be used for carbonic anhydrase (CA)-based CO2-capture (environmental application). This approach would be crucial not only for capturing CO2 via GPI and CA but also for the production of CA enzyme as well as its stabilization and therefore useful for combating the global warming of climate change.



中文翻译:

气候变化:通过糖基磷脂酰肌醇使用碳酸酐酶表达载体进行干预的方法

摘要

气候变化是一个地方平常天气的变化。气候变化不仅对地球自然灾害产生重大影响,也对人类健康产生重大影响。这样,气候危机就不再是未来的问题了。它包括人类排放温室气体(GHG)导致的全球变暖,以及由此导致的天气模式的大规模变化。全球变暖可能由多种原因引起,包括自然原因和人为原因。地球大气中的主要温室气体(按全球平均摩尔分数降序排列)为:水蒸气 (H 2 O)、二氧化碳 (CO 2 )、甲烷 (CH 4 )、一氧化二氮 (N 2 O) 和臭氧(O 3)。今天,世界各地的科学家继续尝试解决气候变化之谜。显然,为了应对气候变化,必须减少工业过程释放到大气中的CO 2量,因为一旦将其添加到大气中,它就会持续影响气候数千年。为此,建议使用表达载体进行干预,通过糖基磷脂酰肌醇 (GPI) 锚定靶向细胞质膜的任何蛋白质。由此产生的 GPI 锚定蛋白可用于研究分子间相互作用,特别是基因-环境相互作用,研究任何化合物对任何感兴趣基因的潜在影响,并可用于基于碳酸酐酶 (CA) 的 CO 2捕获(环境应用)。这种方法不仅对于通过GPI和CA捕获CO 2 至关重要,而且对于CA酶的生产及其稳定性也至关重要,因此对于应对气候变化导致的全球变暖非常有用。

更新日期:2023-07-27
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