Introduction. Cystic Fibrosis Foundation guidelines recommend people with CF perform daily airway clearance. This can be difficult for patients, as some find it time consuming or uncomfortable. Data comparing airway clearance methods are limited. We surveyed patients and their families to understand which methods are preferred and identify obstacles to performing airway clearance. Methods. We designed a REDCap survey and enrolled participants in 2021. Respondents reported information on airway clearance usage, time commitment, and medication use. They rated airway clearance methods for effectiveness, comfort, time commitment, importance, and compatibility with other treatments. The analysis included descriptive statistics and clustering. Results. 60 respondents started and 52 completed the survey. The median patient age was 20 years. Respondents experienced a median of four airway clearance methods in their lifetime, including chest wall oscillation (vest, 92%), manual chest physical therapy (CPT, 88%), forced expiration technique (huff or cough, 77%), and exercise (75%). Past 30-day use was highest for exercise (62%) and vest (57%). The time commitment was generally less than 2 hours daily. Of those eligible for CFTR modulators, 53% reported decreased time commitment to airway clearance after starting treatment. On a scale of 0–100, respondents rated CFTR modulators as their most important treatment (median 99.5), followed by exercise (88). Discussion. Patients and caregivers are familiar with several methods of airway clearance for CF. They report distinct strengths and limitations of each method. Exercise and vest are the most common methods of airway clearance. The use of CFTR modulators may reduce patient-reported time commitment to airway clearance.

中文翻译：

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患者和护理人员对用于囊性纤维化的气道清除方法的看法

介绍。囊性纤维化基金会指南建议患有囊性纤维化的患者每天进行气道清理。这对患者来说可能很困难，因为有些人觉得这很耗时或不舒服。比较气道清除方法的数据有限。我们对患者及其家人进行了调查，以了解哪些方法是首选，并找出执行气道清除的障碍。方法。我们设计了 REDCap 调查并于 2021 年招募参与者。受访者报告了有关气道清除使用情况、时间投入和药物使用的信息。他们对气道清除方法的有效性、舒适度、时间投入、重要性以及与其他治疗的兼容性进行了评估。分析包括描述性统计和聚类。结果。60 名受访者开始了调查，52 名受访者完成了调查。患者的中位年龄为 20 岁。受访者一生中平均经历过四种气道清理方法，包括胸壁振荡（背心，92%）、徒手胸部物理治疗（CPT，88%）、用力呼气技术（呼气或咳嗽，77%）和锻炼（ 75%）。过去 30 天的使用率最高的是锻炼 (62%) 和背心 (57%)。每天投入的时间一般少于2小时。在符合 CFTR 调节剂资格的患者中，53% 的人表示开始治疗后清理气道的时间减少了。在 0-100 分的范围内，受访者将 CFTR 调节剂评为最重要的治疗方法（中位数 99.5），其次是运动（88）。讨论。患者和护理人员熟悉几种清除 CF 气道的方法。他们报告了每种方法的独特优点和局限性。运动和背心是最常见的气道清理方法。CFTR 调节器的使用可能会减少患者报告的气道清除时间。