This study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations might have practical implications for establishment of predictive markers for the response to immunotherapies in malignancies driven by this germ-line mutation.

中文翻译：

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HLA I 类和 II 类对单一种系 BRCA1 突变驱动的恶性肿瘤的可能影响

这项研究提供了第一个免疫遗传学初步证据，表明特定人类白细胞抗原(HLA) I 类和II 类等位基因和单倍型可能与BRCA1 c.5263_5264insC驱动的肿瘤发生相关。观察到的 HLA 关联可能对建立由这种种系突变驱动的恶性肿瘤免疫治疗反应的预测标记具有实际意义。