Background. Dietary patterns play important role in Helicobacter pylori (H. pylori) infection. We aimed to investigate the potential relationship between Dietary Inflammation Index (DII) and H. pylori infection in US adults. Methods. This cross-sectional study was based on National Health and Nutrition Examination Survey (1999–2000). Individuals aged ≥20 years who provided a 24 hr dietary intake history and underwent H. pylori testing were included in the analysis. Multivariate weighted logistic regression analysis, smooth curve fitting, and subgroup analysis were used to investigate the relationship between DII and H. pylori infection. Subgroup analyses were based on demographic and clinical variables. Results. There were 4,000 individuals enrolled in our final analysis. The overall mean age was 45.92 years and 46.77% were males. The overall prevalence of H. pylori infection in the study population was 45.9%. The smooth curve fitting analysis indicated a near-linear relationship between DII and H. pylori. In multivariate weighted logistic regression analysis, the odds ratio (OR) of DII is 1.17 (95% confidence interval (CI), 1.09–1.27) for H. pylori infection. In subgroup analysis, DII still increased the risk of H. pylori infection independently. Conclusions. The increased DII levels were associated with an increased risk of H. pylori infection among US adults. Further studies are needed to elucidate the exact mechanisms of DII and H. pylori infection.

中文翻译：

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美国成人饮食炎症指数与幽门螺杆菌免疫球蛋白 G 血清阳性的关联：一项基于人群的研究

背景。饮食模式在幽门螺杆菌( H. pylori ) 感染中发挥着重要作用。我们的目的是调查美国成年人饮食炎症指数 (DII) 与幽门螺杆菌感染之间的潜在关系。方法。这项横断面研究基于全国健康和营养检查调查（1999-2000 年）。年龄≥20 岁、提供 24 小时饮食摄入史并接受幽门螺杆菌检测的个体纳入分析。采用多元加权logistic回归分析、平滑曲线拟合和亚组分析等方法探讨DII与H. pylori感染的关系。亚组分析基于人口统计和临床变量。结果。我们的最终分析中有 4,000 人参与。总体平均年龄为 45.92 岁，其中 46.77% 为男性。研究人群中幽门螺杆菌感染的总体患病率为45.9%。平滑曲线拟合分析表明DII与幽门螺杆菌之间存在近线性关系。在多变量加权逻辑回归分析中，幽门螺杆菌感染的 DII 优势比 (OR) 为 1.17（95% 置信区间 (CI)，1.09–1.27）。亚组分析中，DII仍独立增加幽门螺杆菌感染风险。结论。DII 水平升高与美国成年人感染幽门螺杆菌的风险增加相关。需要进一步的研究来阐明 DII 和幽门螺杆菌感染的确切机制。