ABSTRACT

Two modified coated membrane sensors were designed and tested. Pantoprazole-phosphotungstate was prepared by a reaction of pantoprazole with phosphotungstic acid in the solvent mediator o-nitrophenyloctyl ether. Two metal oxide nanoparticles nickel oxide and iron oxide nanoparticles, were synthesized from green sources Matricaria recutita flowers and Salvia officinalis leaves extracts, respectively. These nanoparticles were used for the potentiometric assay of pantoprazole sodium in the authentic sample and commercial products. The results showed that the improved nickel oxide and iron oxide nanosensors exhibited linearity using the concentration range of 1.0 × 10⁻⁹–1.0 × 10⁻² and 1.0 × 10⁻¹⁰–1.0 × 10⁻² mol L⁻¹, respectively compared with 1.0 × 10⁻⁶–1.0 × 10⁻² mol L⁻¹ for the normally coated sensor. The lower limits of detection (7.6 × 10⁻⁶, 2.3 × 10⁻¹⁰, 2.8 × 10⁻¹¹ mol L⁻¹) and quantification (1.0 × 10⁻⁶, 1.0 × 10⁻⁹, 1.0 × 10⁻¹⁰ mol L⁻¹) were determined for each of the three proposed sensors. Least squares calculations gave E_mV = (27.266 ± 0.5) log (pantoprazole) + 433.37, E_mV = (30.967 ± 0.3) log (pantoprazole) + 432.24 for the enriched nano-metal oxides, and E_mV = (26.642 ± 0.6) log (pantoprazole) + 443.69 for the conventional type, respectively with correlation coefficients around 0.999 for the proposed sensors. The accuracy and precision of the modified potentiometric systems were estimated and the results showed excellent validity and suitability for the determination of pantoprazole in an authentic sample.

摘要

设计并测试了两种改进的涂层膜传感器。泮托拉唑磷钨酸盐是由泮托拉唑与磷钨酸在溶剂介体邻硝基苯基辛基醚中反应制备的。分别从绿色来源母菊花和丹参叶提取物中合成了两种金属氧化物纳米颗粒氧化镍和氧化铁纳米颗粒。这些纳米颗粒用于真实样品和商业产品中泮托拉唑钠的电位测定。结果表明，改进的氧化镍和氧化铁纳米传感器在1.0 × 10 ^-9 –1.0 × 10 ^-2和1.0 × 10 ^{-10的浓度范围内表现出线性。}–1.0 × 10 ^-2 mol L ^-1 ，分别与正常涂层传感器的1.0 × 10 ^-6 –1.0 × 10 ^-2 mol L ^-1相比。检测下限（7.6 × 10 ^-6、2.3 × 10 ^-10、2.8 × 10 ^-11 mol L ^-1）和定量下限（1.0 × 10 ^-6、1.0 × 10 ^-9、1.0 × 10 ^-10 mol L ⁻¹ ) 是针对三个提议的传感器中的每一个确定的。最小二乘计算得出 E _mV  = (27.266 ± 0.5) log (泮托拉唑) + 433.37, E _mV 对于富集的纳米金属氧化物，E mV = (30.967 ± 0.3) log (泮托拉唑) + 432.24，对于传统类型，E _mV  = (26.642 ± 0.6) log (泮托拉唑) + 443.69，所提出的传感器的相关系数约为 0.999 。对改进的电位测量系统的准确度和精密度进行了评估，结果表明对于真实样品中泮托拉唑的测定具有良好的有效性和适用性。