England is currently in year nine of its 25-year strategy to achieve TB freedom. This talk will speculate on what new tools and approaches could be introduced in the future to help us achieve our goal. Using Defra’s response to the independent review of its TB programme as a starting point and building on the plenary talk by the UK CVO, I will look at some opportunities that could arise under the different aspects of the response. Firstly, how best to help farmers reduce their herd TB risk through better informed purchasing decisions will be considered, including looking at the recent publication of the health ratings for every cattle herd in England. Cattle vaccination, and its associated DIVA test could be the biggest change in Tb control in England in many years while the related development of a molecularly defined tuberculin which could become the default testing reagent. Advances in whole genome sequencing will allow us to sequence the genome of M.bovis isolated from most infected herds in England and these data could unlock a variety of opportunities from tracing the spread of infection to ground-truthing the efficacy of testing and epidemiological assessment of breakdowns. Finally, the move to vaccination as the primary way of controlling TB in badgers with culling used very sparingly will be considered using a case study of how a targeted badger cull successfully removed infection from an area in Cumbria and enabled the switch to vaccination.

中文翻译：

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地平线扫描：英格兰牛结核病控制的下一步是什么？

英国目前正处于其 25 年消除结核病战略的第九年。本次演讲将推测未来可以引入哪些新工具和方法来帮助我们实现目标。以 Defra 对其结核病计划独立审查的回应作为起点，并以英国 CVO 的全体会议发言为基础，我将研究在回应的不同方面可能出现的一些机会。首先，将考虑如何通过更明智的购买决策来最好地帮助农民降低牛群结核病风险，包括查看最近发布的英格兰每个牛群的健康评级。牛疫苗接种及其相关的 DIVA 测试可能是英格兰多年来结核病控制的最大变化，而分子定义的结核菌素的相关开发可能成为默认的测试试剂。全基因组测序的进步将使我们能够对从英格兰大多数受感染牛群中分离出来的牛分枝杆菌的基因组进行测序，这些数据可以释放各种机会，从追踪感染的传播到验证检测和流行病学评估的有效性。故障。最后，将通过一个案例研究来考虑将疫苗接种作为控制獾结核病的主要方法，并很少进行扑杀，该案例研究了有针对性的獾扑杀如何成功地从坎布里亚郡的一个地区消除了感染，并实现了疫苗接种的转变。