Abstract

Although hematopoietic stem cell transplantation (HSCT) has been widely used to treat patients with beta-thalassemia major, evidence showing whether this treatment improves mental health, self esteem and health-related quality of life (HRQoL) is limited. We aimed to describe psychiatric problems, HRQoL and self-esteem scores of patients who have thalassemia and compared with patients who underwent HSCT in the current study. A total of 24 patients with thalassemia major and 13 patients who underwent HSCT at least 2 years ago aged between 7-37 years were included. We used The Children’s Depression Inventory, The Spielberger State-Trait Anxiety Inventory, and Pediatric Quality of LifeTM (PedsQL™) for assesment of children and Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), World Health Organization Quality of Life Scale Brief Version (WHOQOL-BREF) for assessment of adults. We also used Piers Harris Self Concept Scale for children and adults. Psychopathologies are common in both groups (50% in Thalassemia group and 69.2% in HSCT group). Popularity scores in Piers Haris scale of patients in HSCT group were significantly higher compared to thalassemia group (p = 0.03). Additionally, HSCT group had higher scores in physical health subscales of HRQoL in both children and parents’(p = 0.02, p = 0.03 respectively). Our findings suggest improved HRQoL and self-esteem in thalassemia patients after HSCT. However, due to the high prevalence of mental disorders in both groups, we would like to emphasize that clinicians should examine not only the physical but also the psychological state of the patients with thalessemia during the their treatment and follow-up period after HSCT.

摘要

尽管造血干细胞移植（HSCT）已广泛用于治疗重型β地中海贫血患者，但表明这种治疗能否改善心理健康、自尊和健康相关生活质量（HRQoL）的证据有限。我们的目的是描述地中海贫血患者的精神问题、HRQoL 和自尊评分，并与本研究中接受 HSCT 的患者进行比较。总共包括 24 名重型地中海贫血患者和 13 名至少 2 年前接受过 HSCT 的患者，年龄在 7-37 岁之间。我们使用儿童抑郁量表、斯皮尔伯格状态特质焦虑量表和儿科生活质量TM (PedsQL™) 来评估儿童，并使用贝克抑郁量表(BDI)、贝克焦虑量表(BAI)、世界卫生组织生活质量量表用于成人评估的简短版本 (WHOQOL-BREF)。我们还使用了针对儿童和成人的皮尔斯·哈里斯自我概念量表。精神病理学在两组中都很常见（地中海贫血组为 50%，HSCT 组为 69.2%）。HSCT 组患者的 Piers Haris 量表受欢迎度得分显着高于地中海贫血组（p  = 0.03）。此外，HSCT 组儿童和家长的 HRQoL 身体健康分量表得分均较高（分别为p  = 0.02、p  = 0.03）。我们的研究结果表明，HSCT 后地中海贫血患者的 HRQoL 和自尊得到改善。但由于地中海贫血患者的精神障碍患病率较高，我们需要强调的是，临床医生在HSCT后的治疗和随访期间不仅要检查地中海贫血患者的身体状况，还要检查其心理状态。