Cerebral autoregulation (CA) plays a vital role in maintaining cerebral blood flow in response to changes in systemic blood pressure. Impairment of CA following traumatic brain injury (TBI) may exacerbate the injury, potentially impacting patient outcomes. This focused review addresses 4 key questions regarding the measurement, natural history of CA after TBI, and potential clinical implications of CA status and CA-guided management in adults and children with TBI. We examine the feasibility and safety of CA assessment, its association with clinical outcomes, and the potential for reversing deranged CA following TBI. Finally, we discuss how the knowledge of CA status may affect TBI management and outcomes.

中文翻译：

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成人和儿童脑外伤的脑自动调节引导管理。

脑自动调节（CA）在维持脑血流量以响应全身血压变化方面发挥着至关重要的作用。创伤性脑损伤 (TBI) 后 CA 受损可能会加剧损伤，从而可能影响患者的治疗结果。这篇重点综述解决了 4 个关键问题，涉及 TBI 后 CA 的测量、自然史、CA 状态和 CA 指导治疗对患有 TBI 的成人和儿童的潜在临床影响。我们研究了 CA 评估的可行性和安全性、其与临床结果的关联，以及逆转 TBI 后 CA 紊乱的潜力。最后，我们讨论了解 CA 状态如何影响 TBI 管理和结果。