One of the prominent peculiarities of nanoparticles (NPs) is their ability to cross biological barriers. Therefore, the development of NPs with different properties has great therapeutic potential in the area of reproduction because the association of drugs, hormones and other compounds with NPs represents an alternative for delivering substances directly at a specific site and for treatment of reproductive problems. Additionally, lipid-based NPs can be taken up by the tissues of patients with ovarian failure, deep endometriosis, testicular dysfunctions, etc., opening up new perspectives for the treatment of these diseases. The development of nanomaterials with specific size, shape, ligand density and charge certainly will contribute to the next generation of therapies to solve fertility problems in humans. Therefore, this review discusses the potential of NPs to treat reproductive disorders, as well as to regulate the levels of the associated hormones. The possible limitations of the clinical use of NPs are also highlighted.

纳米颗粒 (NP) 的显着特点之一是它们能够跨越生物屏障。因此，开发具有不同特性的纳米粒子在生殖领域具有巨大的治疗潜力，因为药物、激素和其他化合物与纳米粒子的结合代表了直接在特定部位递送物质和治疗生殖问题的替代方案。此外，脂质纳米颗粒可以被卵巢功能衰竭、深部子宫内膜异位症、睾丸功能障碍等患者的组织吸收，为这些疾病的治疗开辟了新的前景。具有特定尺寸、形状、配体密度和电荷的纳米材料的开发无疑将有助于解决人类生育问题的下一代疗法。因此，这篇综述讨论了纳米粒子治疗生殖疾病以及调节相关激素水平的潜力。NP 临床使用可能存在的局限性也得到了强调。