Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge’s secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro. Searching in three different databases, two hundred articles were selected. After screening abstracts, titles and evaluating for eligibility of manuscripts 14 articles were included. The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) and measurement of intracellular reactive oxygen species (ROS). It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro. Scientific evidence of the studies included in this review was accessed by the GRADE analysis. Terpenes play an important ecological role, moreover these molecules have a pharmaceutical and industrial application.

Graphical Abstract

中文翻译：

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从海绵中提取的萜烯具有抗氧化活性：系统评价

海洋生物多样性已成为来自不同海洋生物的生物活性化合物和次生代谢物的非常有前途的资源。海绵的次生代谢物表现出多种生物活性和潜在的药理学特性。本文对文献进行系统综述，重点关注海绵体外抗氧化潜力方面取得的进展。审查是根据 PRISMA 指南进行的。分析的主要纳入标准是鉴定具有体外抗氧化活性的萜类化合物的文章。在三个不同的数据库中进行搜索，选择了两百篇文章。经过筛选摘要、标题并评估稿件合格性后，纳入了 14 篇文章。检测抗氧化活性最常用的分析是清除 2,2-二苯基-1-三硝基苯肼 (DPPH) 活性和细胞内活性氧 (ROS) 的测量。可以在体外鉴定出 17 种具有显着抗氧化活性的萜类化合物。本综述中包含的研究的科学证据是通过 GRADE 分析获得的。萜烯发挥着重要的生态作用，此外这些分子还具有制药和工业应用。

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