Applying the concept of a “natural history” to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics and technology that have occurred over the last one hundred years.

中文翻译：

---

遗传性结直肠癌综合征的自然史：从表型到基因型？我们的立场和未来会怎样？

将“自然史”的概念应用于遗传性结直肠癌是一项有趣的练习，因为处理综合症的方式已经发生了巨大的变化。然而，这个练习是有启发性的，因为它迫使我们深入思考我们现在在哪里，我们曾经去过哪里，最有帮助的是，我们可能要去哪里。在这篇文章中，遗传性结直肠癌的诊断以及内窥镜和手术治疗在其历史和过去一百年来发生的基因组学和技术的变化的背景下进行了讨论。