Synthetic cathinones are a continually evolving family of illicit drugs, with novel analogues frequently being detected. This paper reports the detection of 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one, bk-PBDB (putylone), within solid dosage forms (tablets) seized by law enforcement for the first time in the United Kingdom. The identity of the compound was confirmed via the synthesis of a pure bk-PBDB reference standard and direct spectral comparison by ¹H NMR and GC-EI-MS analysis. A full analytical profiling of bk-PBDB by nuclear magnetic resonance (NMR), attenuated total reflection Fourier-transform infrared (FTIR) spectroscopy and gas chromatography-electron ionisation-mass spectrometry (GC-EI-MS) is reported and shows good concordance between the seized sample and the reference standard. A validated GC-EI-MS method for the routine quantification of the cathinone in bulk forensic samples (LOD: 0.09 μg/mL, LOQ: 0.26 μg/mL) was also developed and using this method, the seized tablets were determined to contain a mixture of bk-PBDB (130.6–135.5 mg/tablet) and caffeine (40.2–43.4 mg/tablet) respectively.

合成卡西酮是一个不断发展的非法药物家族，经常检测到新的类似物。本文报告了执法部门在查获的固体剂型（片剂）中检出 1-(1,3-苯并二氧杂环戊烯-5-基)-2-(丙氨基)丁-1-酮、bk-PBDB（普鲁酮）。第一次在英国。通过合成纯 bk-PBDB 参考标准品并通过¹进行直接光谱比较，确认了该化合物的身份。H NMR 和 GC-EI-MS 分析。报道了通过核磁共振 (NMR)、衰减全反射傅里叶变换红外 (FTIR) 光谱和气相色谱-电子电离-质谱 (GC-EI-MS) 对 bk-PBDB 进行的全面分析，并显示出两者之间良好的一致性检获的样品和参考标准。还开发了一种经过验证的 GC-EI-MS 方法，用于对散装法医样品中的卡西酮进行常规定量（LOD：0.09 μg/mL，LOQ：0.26 μg/mL），并且使用该方法，查获的片剂被确定含有bk-PBDB（130.6–135.5 毫克/片）和咖啡因（40.2–43.4 毫克/片）的混合物。