To explore the relationship between postural changes in lung function and polysomnography (PSG) in children with Duchenne muscular dystrophy (DMD). In this prospective cross-sectional study, children with DMD performed spirometry in sitting and supine positions. A control group of age and gender matched healthy children also underwent postural lung function testing. PSG was performed within six months of spirometry. Seventeen children with DMD, aged 12.3 ± 3 years performed sitting spirometry. 14 (84%) performed acceptable spirometry in the supine position. Mean FEV and FVC were 77% (SD ± 22) and 74% (SD ± 20.4) respectively, with mean% ΔFVC 9% (SD ± 11) (range 2% to 20%), and was significantly greater than healthy controls 4% (n = 30, SD ± 3, < 0.001). PSG data on the 14 DMD children with acceptable supine spirometry showed total AHI 6.9 ± 5.9/hour (0.3 to 29), obstructive AHI 5.2 ± 4.0/hour (0.2 to 10), and REM AHI 14.1 ± -5.3/hour (0.1 to 34.7). ΔFVC(sit–sup) had poor correlation with hypoventilation on polysomnography. Children with DMD and mild restrictive lung disease showed greater postural changes in spirometry than healthy controls but lower supine spirometry was not predictive of sleep hypoventilation.

中文翻译：

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杜氏肌营养不良症儿童肺活量测定的姿势变化能否预测睡眠通气不足？

探讨杜氏肌营养不良症（DMD）儿童肺功能姿势变化与多导睡眠图（PSG）之间的关系。在这项前瞻性横断面研究中，DMD 儿童以坐位和仰卧位进行肺活量测定。年龄和性别匹配的健康儿童对照组也接受了体位肺功能测试。 PSG 在肺活量测定后六个月内进行。 17 名年龄为 12.3 ± 3 岁的 DMD 儿童进行了坐位肺活量测定。 14 名 (84%) 的仰卧位肺量测定结果合格。平均 FEV 和 FVC 分别为 77% (SD ± 22) 和 74% (SD ± 20.4)，平均% ΔFVC 9% (SD ± 11)（范围 2% 至 20%），显着高于健康对照 4 %（n = 30，SD ± 3，< 0.001）。 14 名仰卧位肺量计合格的 DMD 儿童的 PSG 数据显示，总 AHI 6.9 ± 5.9/小时（0.3 至 29），阻塞性 AHI 5.2 ± 4.0/小时（0.2 至 10），REM AHI 14.1 ± -5.3/小时（0.1 至 10）。 34.7）。 ΔFVC（sit-sup）与多导睡眠图上通气不足的相关性较差。患有 DMD 和轻度限制性肺病的儿童在肺活量测定中显示出比健康对照更大的姿势变化，但较低的仰卧位肺活量测定并不能预测睡眠通气不足。