Background To assess the seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women at the Debre Markos Referral Hospital, northwest Ethiopia. Methods A facility-based cross-sectional study was undertaken among pregnant women from March 2020 to May 2021. Sociodemographic and clinical data were collected from randomly selected participants. Five millilitres of blood was collected and an enzyme-linked immunosorbent assay kit was used to test for T. gondii immunoglobulin G (IgG) antibodies. A logistic regression model was computed to identify the risk factors. The adjusted odds ratio (aOR) was estimated along with the 95% confidence interval (CI). A statistically significant association was defined as p<0.05. Results T. gondii IgG antibody positivity was found in 38.8% (n=132) of 340 pregnant women. Contact with cats (AOR 2.5 [95% CI 1.5 to 4.2]), eating raw/undercooked meat (AOR 5.7 [95% CI 3.2 to 10.3]), consuming unwashed vegetables (AOR 4.1 [95% CI 2.1 to 8.0]), a history of abortion (AOR 1.9 [95% CI 1.1 to 3.3]) and drinking water sources (AOR 2.5 [95% CI 1.2 to 5.2]) demonstrated a statistically significant association with T. gondii infection. Conclusions Toxoplasmosis was found to be fairly common in pregnant mothers. Proper cat excreta disposal, not eating raw/undercooked meat, maintaining hand cleanliness and following environmental sanitation protocols could be important to decrease T. gondii infection.

中文翻译：

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埃塞俄比亚西北部德布雷马科斯转诊医院孕妇弓形虫感染的血清阳性率和危险因素

背景 评估埃塞俄比亚西北部 Debre Markos 转诊医院孕妇弓形虫感染的血清阳性率和危险因素。方法 对 2020 年 3 月至 2021 年 5 月的孕妇进行一项基于机构的横断面研究。从随机选择的参与者中收集社会人口学和临床数据。采集5毫升血液，使用酶联免疫吸附测定试剂盒检测弓形虫免疫球蛋白G（IgG）抗体。计算逻辑回归模型来识别风险因素。调整后的比值比 (aOR) 与 95% 置信区间 (CI) 一起进行估计。统计上显着的关联定义为p＜0.05。结果 340名孕妇中弓形虫IgG抗体阳性率为38.8%（n=132）。与猫接触（AOR 2.5 [95% CI 1.5 至 4.2]）、吃生肉/未煮熟的肉（AOR 5.7 [95% CI 3.2 至 10.3]）、食用未清洗的蔬菜（AOR 4.1 [95% CI 2.1 至 8.0]）、流产史（AOR 1.9 [95% CI 1.1 - 3.3]）和饮用水源（AOR 2.5 [95% CI 1.2 - 5.2]）与弓形虫感染存在统计学显着相关性。结论 弓形虫病在孕妇中相当常见。正确处理猫排泄物、不吃生肉/未煮熟的肉、保持手部清洁以及遵循环境卫生规程对于减少弓形虫感染很重要。