Background

This study seeks to estimate whether a chemical has carcinogenic potential; and if it has carcinogenic activity, its carcinogenic efficacy in humans and experimental animals in terms of oral and inhalation slope factors.

Objective

Target chemicals were selected by literature search using Google Scholar, PubMed, ScienceDirect, etc., among the chemicals set by the Ministry of Employment and Labor in Korea as existing chemicals, and the CSF of each chemical was determined using various sites and programs, including EPA Comptox Dashboard and VEGA Hub QSAR (ver. 1.2.3). The CSF value of each chemical obtained using the Comparative Toxicogenomics Database (CTD) was subjected to gene expression analysis for inhalation carcinogenicity according to CSF value priority estimation, and a database (chemical list) was made possible.

Results

Based on KOSHA-MSDS, GHS classification, and reference values for the CSF of each chemical, they were classified and organized using the OncoLogic 9.0 program. The priority of inhalation carcinogenicity was estimated by comparison with gene expression and CSF values, especially those with large inhalation-related values, and carcinogenesis of priority chemicals for inhalation. All the contents were organized and presented in an Excel file, and the priority of inhalation carcinogenicity was estimated through comparison with gene expression, focusing on CSFs, especially those with large inhalation-related values.

Conclusion

Based on the obtained CSF value, the gene expression analysis of each chemical and toxic gene expression analysis of the CTD, inhalation carcinogenicity priority was estimated and a DB (chemical list) was prepared according to the CSF value.

中文翻译：

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通过比较癌症斜率因子来评估致癌物：荟萃分析和系统文献综述

背景

这项研究旨在评估某种化学物质是否具有致癌潜力；如果具有致癌活性，则其对人类和实验动物的致癌效力以口服和吸入斜率因子表示。

客观的

使用 Google Scholar、PubMed、ScienceDirect 等通过文献检索，从韩国雇佣劳动部规定的现有化学品中选择目标化学品，并使用各种网站和程序确定每种化学品的 CSF，包括EPA Comptox 仪表板和 VEGA Hub QSAR（版本 1.2.3）。使用比较毒性基因组学数据库（CTD）获得的每种化学物质的CSF值，根据CSF值优先级估计进行吸入致癌性的基因表达分析，从而使数据库（化学物质列表）成为可能。

结果

根据 KOSHA-MSDS、GHS 分类和每种化学品 CSF 的参考值，使用 OncoLogic 9.0 程序对它们进行分类和组织。通过比较基因表达和CSF值，特别是那些与吸入相关的值较大的值，以及吸入优先化学物质的致癌作用来估计吸入致癌性的优先级。所有内容整理并呈现在Excel文件中，通过与基因表达的比较来估计吸入致癌性的优先级，重点关注CSF，尤其是那些吸入相关值较大的CSF。

结论

根据获得的CSF值，进行各化学物质的基因表达分析和CTD的毒性基因表达分析，估计吸入致癌性优先级，并根据CSF值准备DB（化学物质清单）。