Photoacoustic microscopy is advancing with research on utilizing ultraviolet and visible light. Dual-wavelength approaches are sought for observing DNA/RNA- and vascular-related disorders. However, the availability of high numerical aperture lenses covering both ultraviolet and visible wavelengths is severely limited due to challenges such as chromatic aberration in the optics. Herein, we present a groundbreaking proposal as a pioneering simulation study for incorporating multilayer metalenses into ultraviolet-visible photoacoustic microscopy. The proposed metalens has a thickness of 1.4 µm and high numerical aperture of 0.8. By arranging cylindrical hafnium oxide nanopillars, we design an achromatic transmissive lens for 266 and 532 nm wavelengths. The metalens achieves a diffraction-limited focal spot, surpassing commercially available objective lenses. Through three-dimensional photoacoustic simulation, we demonstrate high-resolution imaging with superior endogenous contrast of targets with ultraviolet and visible optical absorption bands. This metalens will open new possibilities for downsized multispectral photoacoustic microscopy in clinical and preclinical applications.

光声显微镜随着利用紫外线和可见光的研究而不断发展。寻求双波长方法来观察 DNA/RNA 和血管相关疾病。然而，由于光学色差等挑战，覆盖紫外和可见波长的高数值孔径镜头的可用性受到严重限制。在此，我们提出了一项突破性的建议，作为将多层超透镜纳入紫外可见光声显微镜的开创性模拟研究。所提出的超透镜厚度为 1.4 µm，数值孔径高达 0.8。通过排列圆柱形氧化铪纳米柱，我们设计了一种适用于 266 和 532 nm 波长的消色差透射透镜。超透镜实现了衍射极限焦斑，超越了市售物镜。通过三维光声模拟，我们展示了具有紫外和可见光吸收带的目标的高分辨率成像和卓越的内生对比度。这种超透镜将为临床和临床前应用中小型多光谱光声显微镜开辟新的可能性。