Multiple medications have been related to triggering headache attacks or worsening headache frequency or severity in patients with migraine disease. However, the impact of direct oral anticoagulants on headache frequency and severity in patients with migraine disease is unclear. Current literature is scarce and controversial.

中文翻译：

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开始阿哌沙班后先兆偏头痛恶化的病例报告和文献综述。

多种药物与偏头痛患者的头痛发作或头痛频率或严重程度恶化有关。然而，直接口服抗凝剂对偏头痛患者头痛频率和严重程度的影响尚不清楚。目前的文献很少且存在争议。