Abstract

Purpose

This study aimed to explore the association between controlling nutritional status (CONUT) score and chronic kidney disease (CKD) in type-2 diabetes mellitus (T2DM) patients.

Methods

This was a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES). The data on demographic characteristics, physical examination, lifestyle behaviors, comorbidities, medicine use, laboratory values, and energy were extracted. Nutritional status was assessed using CONUT score, and patients were divided into normal nutrition group and malnutrition group. Association between CONUT score and CKD in T2DM patients was assessed using logistic regression analysis, and odds ratio (OR) and 95% confidence intervals (CIs) were reported. Subgroup analysis based on age, body mass index (BMI), cardiovascular disease (CVD), diabetic retinopathy, and hyperlipidemia was performed.

Results

A total of 4581 patients were finally included for analysis. In the adjusted model, high CONUT score was found to be associated with the high odds of CKD (OR = 1.28, 95% CI 1.05–1.56). Also, high CONUT score was associated with the high odds of CKD in T2DM patients with age ≥ 65 years, with BMI < 25 kg/m², with BMI ≥ 25 kg/m², without CVD, without diabetic retinopathy, with hyperlipidemia, or without hyperlipidemia (all P < 0.05).

Conclusions

Malnutrition was associated with the high odds of CKD in T2DM patients, indicating that actively monitoring the nutritional status is important for the management of CKD in T2DM patients.

中文翻译：

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糖尿病患者控制营养状况评分与慢性肾脏病之间的关联：基于国家健康和营养检查调查的横断面研究

摘要

目的

本研究旨在探讨2型糖尿病（T2DM）患者控制营养状况（CONUT）评分与慢性肾脏病（CKD）之间的关联。

方法

这是一项基于国家健康和营养检查调查 (NHANES) 的横断面研究。提取了人口特征、体检、生活方式、合并症、药物使用、实验室值和能量的数据。采用CONUT评分评估营养状况，将患者分为营养正常组和营养不良组。使用逻辑回归分析评估 T2DM 患者 CONUT 评分与 CKD 之间的关联，并报告比值比 (OR) 和 95% 置信区间 (CI)。根据年龄、体重指数（BMI）、心血管疾病（CVD）、糖尿病视网膜病变和高脂血症进行亚组分析。

结果

最终共有4581名患者纳入分析。在调整后的模型中，发现高 CONUT 评分与 CKD 的高几率相关（OR = 1.28，95% CI 1.05–1.56）。此外，高 CONUT 评分与年龄 ≥ 65 岁、BMI < 25 kg/m ²、BMI ≥ 25 kg/m ²、无 CVD、无糖尿病视网膜病变、高脂血症、或无高脂血症（均P  <0.05）。

结论

营养不良与 T2DM 患者 CKD 的高发病率相关，表明积极监测营养状况对于 T2DM 患者 CKD 的管理非常重要。