Abstract

Nanoemulsions (NEs) of simple compositions have been obtained, in which polyoxyethylene(4) lauryl ether (Brij L4, Br-4) plays the roles of a dispersed phase and a stabilizer, while water is a dispersion medium. The following properties of NEs have been studied: particle size distribution; solubilization capacity; and transport properties with respect to the lipophilic biocide, chlorhexidine (CH) base. The long-term aggregative stability of NEs (for several months) and the efficient mass transfer of CH by the NE dispersed phase particles in the aqueous medium have been confirmed. A unique phenomenon of a spontaneous decrease in the sizes of NE droplets upon solubilization of CH has been found, with the particle average diameter decreasing from 52 ± 6 to 19 ± 3 nm. The reason for this phenomenon is the formation of complexes between Br-4 and CH molecules on the surface of the droplets, with the complexes being better soluble in water than Br-4. Brij L4 molecules included into the complexes are transferred from the droplet surface into the dispersion medium, thus leading to the decrease in the droplet sizes. The complexation occurs due to the formation of multiple N⋅⋅⋅H⋅⋅⋅O hydrogen bonds. From 84 to 96% of the biocide solubilized in the NEs is also localized in the polyoxyethylated layer of Br-4 droplets due to H-bonds.

中文翻译：

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含溶解洗必太碱的聚氧乙烯(4)月桂基醚纳米乳液

摘要

获得了组成简单的纳米乳液（NE），其中聚氧乙烯（4）月桂基醚（Brij L4，Br-4）起到分散相和稳定剂的作用，而水是分散介质。研究了NE的以下特性：粒度分布；增溶能力；以及相对于亲脂性杀菌剂氯己定 (CH) 碱的运输特性。NEs的长期聚集稳定性（几个月）以及NE分散相颗粒在水介质中对CH的有效传质已得到证实。发现了 CH 溶解后 NE 液滴尺寸自发减小的独特现象，颗粒平均直径从 52 ± 6 nm 减小到 19 ± 3 nm。造成这种现象的原因是Br-4和CH分子在液滴表面形成了络合物，该络合物比Br-4更易溶于水。复合物中包含的 Brij L4 分子从液滴表面转移到分散介质中，从而导致液滴尺寸减小。络合作用是由于形成多个 N⋅⋅⋅H⋅⋅⋅O 氢键而发生的。由于氢键，溶解在 NE 中的 84% 至 96% 的杀菌剂也位于 Br-4 液滴的聚氧乙基化层中。络合作用是由于形成多个 N⋅⋅⋅H⋅⋅⋅O 氢键而发生的。由于氢键，溶解在 NE 中的 84% 至 96% 的杀菌剂也位于 Br-4 液滴的聚氧乙基化层中。络合作用是由于形成多个 N⋅⋅⋅H⋅⋅⋅O 氢键而发生的。由于氢键，溶解在 NE 中的 84% 至 96% 的杀菌剂也位于 Br-4 液滴的聚氧乙基化层中。