Bixafen (BIX), a widely used succinate dehydrogenase inhibitor (SDHI) in agricultural disease control, has garnered significant attention due to its known hazardous effects on aquatic organisms. In this study, we exposed zebrafish embryos to 0.1, 0.2, and 0.3 μM BIX, to explore the impact of BIX on liver and pancreas. The results showed that BIX caused deformities and dysfunction in zebrafish embryos, including spinal curvature, pericardial edema, heart rate decrease, and hatching delay. Moreover, BIX significantly affected the development of the liver and pancreas in zebrafish and downregulated zebrafish fabp10a gene expression. Overall, this study presents strong evidence for BIX’s potential toxicity to zebrafish liver and pancreas. The results may provide new insights into the evaluation of BIX’S impact on aquatic organisms.

Bixafen (BIX) 是一种在农业病害防治中广泛使用的琥珀酸脱氢酶抑制剂 (SDHI)，由于其已知对水生生物的危害而引起了广泛关注。在本研究中，我们将斑马鱼胚胎暴露于 0.1、0.2 和 0.3 μM BIX，以探讨 BIX 对肝脏和胰腺的影响。结果表明，BIX会导致斑马鱼胚胎畸形和功能障碍，包括脊柱弯曲、心包水肿、心率下降和孵化延迟。此外，BIX 显着影响斑马鱼肝脏和胰腺的发育，并下调斑马鱼fabp10a基因表达。总体而言，这项研究为 BIX 对斑马鱼肝脏和胰腺的潜在毒性提供了有力的证据。该结果可能为评估 BIX 对水生生物的影响提供新的见解。