Objectives: Previous studies have suggested a potential link between glycan levels and pancreatic cancer. To better characterize this relationship, we performed a study to evaluate the association between genetically predicted N-glycan levels in plasma and pancreatic cancer risk.

Methods: Using genetic variants identified to be associated with plasma N-glycan levels in large genome-wide association studies (GWAS) as instruments, we evaluated the associations between plasma N-glycans and pancreatic cancer risk by analyzing data from 8275 pancreatic cancer cases and 6723 controls.

Results: We observed that lower predicted PGP110 levels were significantly associated with an increased risk of pancreatic cancer after adjusting for multiple comparisons.

Conclusions: Our study did not support strong associations between human plasma N-glycans and the risk of pancreatic cancer, although the observed association with PGP110 warrants further investigation.

Simple summary

Objectives: Pancreatic cancer is a fatal malignancy. Therefore, there is an urgent need to better understand its risk factors and identify markers for better predicting individual risk of developing this cancer. Previous research has suggested that glycans may play a role in the development of pancreatic cancer. To better understand their relationship, we conducted a study to assess the associations between N-glycan levels predicted by genetic factors and pancreatic cancer risk. Methods: We used genetic factors related to blood N-glycan levels as instruments. We further evaluated the associations between plasma N-glycans and pancreatic cancer risk by analyzing data from 8275 pancreatic cancer patients and 6723 controls. Results: We only observed one association between predicted levels of PGP110 and pancreatic cancer risk. Conclusions: Our study did not support strong associations between N-glycan levels and pancreatic cancer risk, although the observed association with PGP110 can be further studied.

目的：先前的研究表明聚糖水平与胰腺癌之间存在潜在联系。为了更好地表征这种关系，我们进行了一项研究来评估基因预测的血浆 N-聚糖水平与胰腺癌风险之间的关联。

方法：利用大型全基因组关联研究 (GWAS) 中确定的与血浆 N-聚糖水平相关的遗传变异作为工具，我们通过分析 8275 例胰腺癌病例的数据来评估血浆 N-聚糖与胰腺癌风险之间的关联。 6723控制。

结果：我们观察到，在调整多重比较后，较低的预测 PGP110 水平与胰腺癌风险增加显着相关。

结论：我们的研究并不支持人血浆 N-聚糖与胰腺癌风险之间存在很强的关联，尽管观察到的与 PGP110 的关联值得进一步研究。

简单总结

目标：胰腺癌是一种致命的恶性肿瘤。因此，迫切需要更好地了解其风险因素并确定标记物，以更好地预测个体患这种癌症的风险。先前的研究表明聚糖可能在胰腺癌的发展中发挥作用。为了更好地了解它们之间的关系，我们进行了一项研究来评估遗传因素预测的 N-聚糖水平与胰腺癌风险之间的关联。方法：我们使用与血液 N-聚糖水平相关的遗传因素作为工具。我们通过分析 8275 名胰腺癌患者和 6723 名对照者的数据，进一步评估了血浆 N-聚糖与胰腺癌风险之间的关联。结果：我们仅观察到 PGP110 的预测水平与胰腺癌风险之间的一种关联。结论：