Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development, and biological markers. So, we aimed to synthesize and characterize new 4-(Het)aryl-substituted Pyrazole-quinolinones. Methods: Synthesis of One-Pot Multicomponent Reaction was carried out with the reaction of 5-amino-3-methyl-1H-pyrazole 1a, and 5-amino-3-phenyl-1H-pyrazole 1b and dimedone 2 with some (het)aryl aldehydes 3 using ethanol. Characterizations such as the linear structures and the regiospecificity of the reactions were determined by using NMR, GC-MS, IR, and UV measurements. Conclusion: This research will be very useful for all methods and procedures using multi one-point reactions which are very popular in the synthesis of heterocyclic systems for pyrazole- quin-oline skeleton synthesis.

中文翻译：

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一锅多组分反应：4-(Het)芳基取代的吡唑并喹啉酮的高效合成

简介：吡唑并喹啉酮（PQ）是一类多用途的有机化学，人们发现它们由于其支架而具有非常先进的功能，有望作为选择性化合物，并且表现出低毒性和可观的临床前景。此外，这些化合物在分析试剂、技术、药物开发和生物标记等不同应用中发挥着重要作用。因此，我们的目的是合成和表征新的 4-(Het) 芳基取代的吡唑喹啉酮。方法：以5-氨基-3-甲基-1H-吡唑1a、5-氨基-3-苯基-1H-吡唑1b和双甲酮2与一些(h​​et)反应进行一锅多组分反应合成。使用乙醇合成芳基醛3。通过使用 NMR、GC-MS、IR 和 UV 测量来确定反应的线性结构和区域特异性等表征。结论：这项研究对于使用多一点反应的所有方法和程序非常有用，这些方法和程序在吡唑-喹啉骨架合成的杂环体系的合成中非常流行。