Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5-24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study.,Journal of Stroke

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Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5-24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study.
Journal of Stroke ( IF 8.2 ) Pub Date : 2023-08-24 , DOI: 10.5853/jos.2023.00668
Lu Wang ₁ , Ying-Jie Dai ₁ , Yu Cui ₁ , Hong Zhang ₂ , Chang-Hao Jiang ₃ , Ying-Jie Duan ₄ , Yong Zhao ₅ , Ye-Fang Feng ₆ , Shi-Mei Geng ₇ , Zai-Hui Zhang ₈ , Jiang Lu ₉ , Ping Zhang ₁₀ , Li-Wei Zhao ₁₁ , Hang Zhao ₁₂ , Yu-Tong Ma ₇ , Cheng-Guang Song ₁₃ , Yi Zhang ₁₄ , Hui-Sheng Chen ₁

Affiliation

Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Department of Neurology, Liaoning Health Industry Group Fukuang General Hospital, Fushun, China.
Department of Neurology, Lvshunkou Traditional Chinese Medicine Hospital, Dalian, China.
Department of Neurology, Liaoning Health Industry Group Fuxinkuang General Hospital, Fuxin, China.
Department of Neurology, Haicheng Traditional Chinese Medicine Hospital, Haicheng, China.
Department of Neurology, Huludao Second People's Hospital, Huludao, China.
Department of Neurology, Beipiao Central Hospital, Beipiao, China.
Department of Neurology, Xiuyan County Central People's Hospital, Anshan, China.
Department of Neurology, Linghai Dalinghe Hospital, Jinzhou, China.
Department of Neurology, Fuxin Central Hospital, Fuxin, China.
Department of Neurology, Anshan Changda Hospital, Anshan, China.
Department of Neurology, General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, Benxi, China.
Department of Neurology, Benxi Central Hospital, Benxi, China.
Department of Neurology, Tieling County Central Hospital, Tieling, China Background.

Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of intravenous TNK for AIS within 4.5 to 24 hours of onset.

中文翻译：

静脉注射替奈普酶治疗发病 4.5-24 小时内的急性缺血性中风 (ROSE-TNK)：一项 2 期、随机、多中心研究。

静脉注射替奈普酶 (TNK) 对于发病后 4.5 小时以上的急性缺血性卒中 (AIS) 的疗效尚未得到充分证实。本研究旨在确定静脉 TNK 在 AIS 发病 4.5 至 24 小时内的效果。

更新日期：2023-08-24

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