Circulating microvesicles (MVs) have been studied in heterogeneous, divergent, and rather small patient populations with cardiovascular risk . Therefore, we measured endothelial (EMVs), platelet (PMVs) and erythrocyte (RMVs) MVs in patients with divergent cardiovascular risk. We then compared them to coronary artery disease (CAD) and healthy subjects and identified independent MVs’ predictors. We enrolled consecutive patients from our Cardiology, Hypertension, Diabetic, Rheumatic, and Nephrology Outpatient Units with MVs measurements. Central blood pressure (BP) was measured by either applanation tonometry or Mobil-O-graph device, while MVs by a standardized flow cytometry protocol. We studied 369 participants with increased cardiovascular risk: 63 with high cardiovascular risk (47 diabetes mellitus type II/DM and 16 end-stage renal disease/ESRD), 92 with chronic inflammatory disorders and 73 with untreated essential hypertension/UEH. We further included 53 subjects with CAD and 87 otherwise healthy individuals. All MVs were lower in patients with increased cardiovascular risk compared to CAD, showing predictive value with high sensitivity and specificity. Furthermore, PMVs and EMVs were increased in patients with cardiovascular risk compared to healthy individuals. DM and ESRD patients had increased EMVs versus UEH and chronic inflammatory disorders. In the whole study population, RMVs were associated only with history of essential hypertension. In multivariate analysis, systolic BP predicted PMVs. Aage, systolic BP, and DM predicted EMVs. In a large population of patients with divergent cardiovascular risk, MVs are independently associated with systolic blood pressure.

循环微泡 (MV) 已在具有心血管风险的异质、不同且相当小的患者群体中进行了研究。因此，我们测量了具有不同心血管风险的患者的内皮细胞 (EMV)、血小板 (PMV) 和红细胞 (RMV) MV。然后，我们将它们与冠状动脉疾病 (CAD) 和健康受试者进行比较，并确定独立的 MV 预测因子。我们连续招募了来自心脏病科、高血压科、糖尿病科、风湿科和肾科门诊的患者进行 MV 测量。中心血压 (BP) 通过压平眼压计或 Mobil-O-graph 装置测量，而 MV 通过标准化流式细胞术方案测量。我们研究了 369 名心血管风险增加的参与者：63 名患有高心血管风险（47 名患有 II 型糖尿病/DM，16 名患有终末期肾病/ESRD），92 名患有慢性炎症性疾病，73 名患有未经治疗的原发性高血压/UEH。我们进一步纳入了 53 名患有 CAD 的受试者和 87 名其他健康的个体。与 CAD 相比，心血管风险增加的患者的所有 MV 均较低，显示出具有高敏感性和特异性的预测价值。此外，与健康个体相比，有心血管风险的患者的 PMV 和 EMV 增加。与 UEH 和慢性炎症性疾病相比，DM 和 ESRD 患者的 EMV 有所增加。在整个研究人群中，RMV 仅与原发性高血压病史相关。在多变量分析中，收缩压可预测 PMV。Aage、收缩压和 DM 预测 EMV。在大量具有不同心血管风险的患者中，MV 与收缩压独立相关。