Hibiscus sabdariffa Linn. Extract Increases the mRNA Expression of the Arcuate Nucleus Leptin Receptor and is Predicted in silico as an Anti-obesity Agent,Current Computer-Aided Drug Design

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Hibiscus sabdariffa Linn. Extract Increases the mRNA Expression of the Arcuate Nucleus Leptin Receptor and is Predicted in silico as an Anti-obesity Agent
Current Computer-Aided Drug Design ( IF 1.7 ) Pub Date : 2023-09-19 , DOI: 10.2174/1573409920666230822115144
Neng Tine Kartinah ₁ , Suci Anggraini ₂ , Fadilah Fadilah ₃ , Rickie Rickie _{2,

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Affiliation

Background: Leptin is predominant in regulating body weight by stimulating energy expenditure through its neuronal action in the brain. Moreover, it is projected to adipose tissue and induces adipocyte browning by activating the β3-adrenergic receptor (β3AR). However, the expression of leptin receptor (Lep-R) and β3AR in people with obesity is downregulated. Aim: We hypothesized that Hibiscus sabdariffa Linn. extract (HSE) would increase hypothalamus arcuate nucleus (ARC) Lep-R and white adipose tissue (WAT) β3AR mRNA expression in DIO rats. This study also analyzed the potency of H. sabdariffa bioactive compounds as activators of Lep-R and β3AR by an in-silico experiment. Methods: Twenty-four male Sprague-Dawley rats were divided into four groups: Control (standard food), DIO (high-fat diet), DIO-Hib200 (HFD+HSE 200 mg/kg BW), and DIO-Hib400 (HFD+HSE400 mg/kg BW). HSE was administered orally for five weeks, once a day. Results: HSE administration significantly (p

中文翻译：

木槿。提取物可增加弓状核瘦素受体的 mRNA 表达，并通过计算机预测可作为抗肥胖剂

背景：瘦素通过其在大脑中的神经元作用刺激能量消耗，在调节体重方面发挥着主导作用。此外，它投射到脂肪组织并通过激活β3-肾上腺素受体（β3AR）诱导脂肪细胞褐变。然而，肥胖人群中瘦素受体（Lep-R）和β3AR的表达下调。目的：我们假设 Hibiscus sabdariffa Linn。提取物 (HSE) 会增加 DIO 大鼠下丘脑弓状核 (ARC) Lep-R 和白色脂肪组织 (WAT) β3AR mRNA 的表达。本研究还通过计算机模拟实验分析了 H. sabdariffa 生物活性化合物作为 Lep-R 和 β3AR 激活剂的效力。方法：24只雄性Sprague-Dawley大鼠分为四组：对照组（标准食物）、DIO（高脂饮食）、DIO-Hib200（HFD+HSE 200 mg/kg BW）和DIO-Hib400（HFD） +HSE400 毫克/千克体重）。HSE 口服给药五周，每天一次。结果：HSE 管理显着 (p

更新日期：2023-09-19

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