Whipple's disease (WD) is a rare and potentially fatal infectious disease caused by Tropheryma whipplei. It is characterized by a long prodromal phase that mimics a rheumatological disease, often leading to immunosuppressant treatment. Immune reconstitution inflammatory syndrome (IRIS) is currently the most important complication of WD, requiring prompt recognition and treatment as it can be fatal. However, epidemiological data on IRIS are scarce. We aimed to identify the clinical and laboratory predictors of IRIS at WD diagnosis and to evaluate whether the prevalence of IRIS has changed over time.

中文翻译：

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Whipple 病患者免疫重建炎症综合征的临床和实验室预测因素及患病率

惠普尔氏病 (WD) 是一种罕见且可能致命的传染病，由惠普尔氏蠕虫 (Tropheryma Whipplei)引起。其特征是类似于风湿病的漫长前驱期，通常需要免疫抑制剂治疗。免疫重建炎症综合征 (IRIS) 是目前 WD 最重要的并发症，需要及时识别和治疗，因为它可能是致命的。然而，关于 IRIS 的流行病学数据很少。我们的目的是确定 WD 诊断时 IRIS 的临床和实验室预测因素，并评估 IRIS 的患病率是否随时间变化。