Short-chain fatty acids are regarded as promising feed additives, acetate is one of them. The aim of this research was to investigate the effect of sodium acetate (SA) on Onychostoma macrolepis fed a high-fat diet. O. macrolepis (2.1 ± 0.1 g) were reared in 12 aquariums (three aquarium/group, 15 fish/aquarium), fed a high-fat diet (control), and a high-fat diet supplemented with 0.5%, 1.0%, or 2.0% SA for 56 days. Diet supplemented with 1.0% SA significantly increased the weight gain of O. macrolepis fed the high-fat diet. Dietary SA reduced serum alanine aminotransferase, aspartate aminotransferase, and triglyceride (TG) concentrations. The addition of 1.0% and 2.0% SA significantly decreased non-esterified fatty acids (NEFA) and TG concentrations in liver. Dietary SA (1.0% and 2.0%) significantly improved total antioxidant capacity and total superoxide dismutase activities in the liver. In comparison to the control group, the addition of 1.0% and 2.0% SA significantly up-regulated lipolysis gene expression levels in the liver. These findings suggest that high fat diets supplemented with 1%–2.0% SA can improve growth, liver health, and antioxidant capacity in O. macrolepis.

中文翻译：

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不同乙酸钠浓度对高脂饲料喂养的大鳞甲鱼幼鱼生长、抗氧化能力和脂肪沉积的影响

短链脂肪酸被认为是很有前途的饲料添加剂，乙酸盐就是其中之一。本研究的目的是调查醋酸钠 (SA) 对高脂饲料喂养的大鳞甲鱼的影响。 O. macrolepis (2.1 ± 0.1 g) 在 12 个水族箱中饲养（3 个水族箱/组，15 条鱼/水族箱），饲喂高脂饲料（对照），并在高脂饲料中添加 0.5%、1.0%、或 2.0% SA，持续 56 天。添加1.0%SA的饲料显着增加了高脂饲料喂养的大鳞鱼的增重。膳食SA可降低血清丙氨酸转氨酶、天冬氨酸转氨酶和甘油三酯(TG)浓度。添加1.0%和2.0% SA显着降低了肝脏中非酯化脂肪酸(NEFA)和TG浓度。膳食SA（1.0%和2.0%）显着提高了肝脏的总抗氧化能力和总超氧化物歧化酶活性。与对照组相比，添加1.0%和2.0% SA显着上调肝脏中脂肪分解基因的表达水平。这些研究结果表明，添加 1%–2.0% SA 的高脂肪饮食可以改善大鳞鱼的生长、肝脏健康和抗氧化能力。