With the advantages of controllable atomic composition, unique molecular-like properties, and excellent biocompatibility, atomic precision Au cluster is an ideal candidate for developing materials with customized biological functions to meet the needs of precision medicine. To achieve the rational design of functional materials through structural regulation at the atomic level, it is important to clarify the relationship between the structure and properties of Au clusters. With the development of synthesis methodology, a variety of structural regulation methods of Au clusters have been developed, providing new opportunities for structure–activity relationship establishment and precision medicine application. This review introduces the synthesis and structure regulation methods of atomic precision Au clusters, and the effects of structural regulation on the physicochemical properties are further described. At the same time, the applications of Au clusters in precision medicine, including the detection of biomolecules, functional imaging, and disease therapy are discussed, as well as the recent studies around their biosafety. At last, it also briefly summarizes the current problems and development directions. The present work provides potential theoretical guidance for the rational design of Au clusters with customized biological functions and is of great significance for broadening their applications in the field of precision medicine.

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原子精密金纳米团簇：迈向定制合成、精准医学

原子精密金团簇具有可控的原子组成、独特的类分子性质和优异的生物相容性等优点，是开发具有定制生物功能的材料以满足精准医疗需求的理想选择。为了通过原子水平的结构调控实现功能材料的合理设计，阐明Au簇的结构与性能之间的关系具有重要意义。随着合成方法学的发展，多种Au团簇的结构调控方法被开发出来，为构效关系的建立和精准医学应用提供了新的机遇。本文介绍了原子精密Au团簇的合成和结构调控方法，并进一步描述了结构调控对理化性质的影响。同时，讨论了金团簇在精准医学中的应用，包括生物分子检测、功能成像和疾病治疗，以及最近围绕其生物安全性的研究。最后还简要总结了当前存在的问题和发展方向。目前的工作为合理设计具有定制生物学功能的Au团簇提供了潜在的理论指导，对于拓宽其在精准医学领域的应用具有重要意义。讨论了其生物安全性和疾病治疗，以及最近的研究。最后还简要总结了当前存在的问题和发展方向。目前的工作为合理设计具有定制生物学功能的Au团簇提供了潜在的理论指导，对于拓宽其在精准医学领域的应用具有重要意义。讨论了其生物安全性和疾病治疗，以及最近的研究。最后还简要总结了当前存在的问题和发展方向。目前的工作为合理设计具有定制生物学功能的Au团簇提供了潜在的理论指导，对于拓宽其在精准医疗领域的应用具有重要意义。