Abstract

Purpose

With the inclusion of primary HPV testing in 2018 U.S. Preventive Services Taskforce guidelines, at-home HPV self-sampling may provide a future option for cervical cancer screening, especially among hard-to-reach populations in the U.S. This study evaluated the association of implementation preferences with the willingness of at-home HPV self-sampling.

Methods

We conducted a cross-sectional study in 2018 among U.S. women ages 30–65 years, without a hysterectomy (n = 812). The outcome was willingness to have at-home HPV self-sampling (yes/no). Primary predictor variables (i.e., information source, methods of payment, methods of sending or receiving self-sampling kits) measured self-sampling implementation preferences. Adjusted logistic regression identified associations with willingness to have at-home HPV self-sampling.

Results

Participants who preferred receiving information from healthcare providers (OR = 2.64; 95% CI 1.54,4.52) or from media or other sources (OR = 2.30; 95% CI 1.51,3.48) had higher HPV self-sampling willingness than participants who did not prefer those sources. Participants who did not want to pay for self-sampling (OR = 0.21; 95% CI 0.14,0.32) or did not know if they would pay for self-sampling (OR = 0.35; 95% CI 0.22,0.54) had lower odds of HPV self-sampling willingness compared to participants willing to pay. Participants who did not know which method they preferred for receiving a self-sampling kit (OR = 0.15, 95% CI 0.07,0.31) or preferred delivering the sample to the lab themselves (OR = 0.59; 95% CI 0.36,0.96) had lower odds for self-sampling willingness compared to participants who preferred the mail.

Conclusion

Understanding the preferences of women regarding the implementation of HPV self-sampling can improve uptake in cervical cancer screening, especially among hard-to-reach populations.

中文翻译：

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美国女性 HPV 自我采样：实施偏好

摘要

目的

随着 2018 年美国预防服务工作组指南中纳入初级 HPV 检测，家庭 HPV 自我采样可能为宫颈癌筛查提供未来的选择，特别是在美国难以接触到的人群中。这项研究评估了实施的关联性偏好并愿意在家进行​​ HPV 自我采样。

方法

我们于 2018 年对 30-65 岁未接受子宫切除术的美国女性进行了一项横断面研究 ( n  = 812)。结果是愿意在家进行​​ HPV 自我采样（是/否）。主要预测变量（即信息来源、支付方式、发送或接收自采样套件的方法）测量自采样实施偏好。调整后的逻辑回归确定了与在家进行 HPV 自我采样的意愿之间的关联。

结果

喜欢从医疗保健提供者（OR = 2.64；95% CI 1.54,4.52）或媒体或其他来源（OR = 2.30；95% CI 1.51,3.48）接收信息的参与者比不喜欢从医疗保健提供者那里接收信息的参与者具有更高的 HPV 自我采样意愿更喜欢这些来源。不想支付自我采样费用（OR = 0.21；95% CI 0.14,0.32）或不知道是否愿意支付自我采样费用（OR = 0.35；95% CI 0.22,0.54）的参与者的几率较低与愿意付费的参与者相比，HPV 自我采样意愿的差异。不知道自己喜欢哪种方法接收自我采样试剂盒的参与者（OR = 0.15，95% CI 0.07,0.31）或喜欢自己将样品运送到实验室（OR = 0.59；95% CI 0.36,0.96）的参与者与喜欢邮寄的参与者相比，愿意自我采样的几率较低。

结论

了解女性对实施 HPV 自我采样的偏好可以提高宫颈癌筛查的采用率，尤其是在难以接触的人群中。