Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization in young children and represents a substantial health-care burden around the world. Advances in research have helped identify the prefusion F protein as the key target component in RSV immunization. In this article, we review the previous, current, and ongoing research efforts for immunization against RSV in children. We present the different types of immunization which include monoclonal antibodies, maternal immunization and vaccines while addressing the challenges of preventing RSV infections in the pediatric population.

中文翻译：

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儿童呼吸道合胞病毒 (RSV) 的预防性治疗：我们现在在哪里？

呼吸道合胞病毒 (RSV) 是导致幼儿住院的主要原因，在全世界范围内造成了巨大的医疗负担。研究进展有助于确定融合前 F 蛋白是 RSV 免疫的关键靶标成分。在本文中，我们回顾了之前、当前和正在进行的儿童 RSV 免疫研究工作。我们介绍不同类型的免疫接种，包括单克隆抗体、母体免疫和疫苗，同时解决预防儿科人群 RSV 感染的挑战。