Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats,Xenobiotica

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Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats
Xenobiotica ( IF 1.8 ) Pub Date : 2023-09-05 , DOI: 10.1080/00498254.2023.2253314
Shuhei Fukuno ₁ , Katsuhito Nagai ₁ , Akemi Kurotobi ₁ , Yuki Sahori ₁ , Ryo Nakagawa ₁ , Rena Nomura ₁ , Takuya Ito ₂ , Hiroki Konishi ₁

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Danazol (DNZ) is a synthetic androgen derivative used for the treatment of intractable hematological disorders. In this study, we investigated the effects of DNZ on CYP3A activity in hepatic and sm...

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