Background: Post-mortem examination of the brain is a key strategy to increase our understanding of the neurobiology of mental disorders. While extensive post-mortem research has been under taken on some mental disorders, others appear to have been relatively neglected. Objective: The objective of the study was to conduct a systematic review of post-mortem research on obsessive-compulsive disorder (OCD). Methods: A systematic review was performed in accordance with PRISMA guidelines to provide an overview of quantitative, qualitative, or mixed methods primary research studies on OCD. Search platforms included NCBI Pubmed, SCOPUS, and Web of Science. Results: A total of 52 publications were found, and after the removal of works not meeting the inclusion criteria, six (6) peer-reviewed publications remained. These post-mortem studies have provided data on DNA methylation, cellular and molecular alterations, and gene expression profiling in brain areas associated with OCD. Discussion and Conclusion: Included studies highlight the potential value of post-mortem brains from well-characterized individuals with OCD and suggest the need for additional work in this area.

中文翻译：

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使用死后脑组织研究强迫症：系统评价

背景：大脑尸检是增进我们对精神障碍神经生物学了解的关键策略。虽然对某些精神障碍进行了广泛的尸检研究，但其他精神障碍似乎相对被忽视了。目的：本研究的目的是对强迫症（OCD）的尸检研究进行系统回顾。方法：根据 PRISMA 指南进行系统评价，以概述强迫症的定量、定性或混合方法初步研究。检索平台包括 NCBI Pubmed、SCOPUS 和 Web of Science。结果：共找到 52 篇出版物，删除不符合纳入标准的作品后，剩下六 (6) 篇同行评审出版物。这些尸检研究提供了有关强迫症相关大脑区域 DNA 甲基化、细胞和分子改变以及基因表达谱的数据。讨论和结论：纳入的研究强调了具有良好特征的强迫症患者死后大脑的潜在价值，并表明需要在这一领域开展更多工作。