Klebsiella pneumoniae (Kp) associated with hospital acquired infections are extensively-drug resistant (XDR), making treatment problematic. Understanding the genetic epidemiology of XDR -Kp can determine their potential to be hypervirulent (hv) through the presence of siderophores. We characterized genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated urinary tract infection in an Indian healthcare facility. 18 organisms comprised STs: ST14 (9/18), ST147 (5/18), ST231 (2/18), ST2096 (1/18), and ST25 (1/18). Many patients in one ward were infected with the same ST, indicating a common infection source. Some patients had recurrent infections with multiple STs that were circulating in that ward, providing evidence for hospital transmission. Beta lactamase genes (bla_CTX-M-1, bla_SHV, and bla_ampH) were present in all isolates. bla_NDM-1 was present in isolates 15/18, bla_OXA-1 was present in isolates 16/18, bla_TEM-1D was present in 13/18 isolates, and bla_OXA-48 was present in isolates 14,19 and 30. Disruption of mgrB with various IS elements was responsible for colistin resistance in 6 isolates. The most common K type among these isolates was K2 (10/18). One XDR convergent hv-Kp ST2096 was associated with prolonged hospitalisation (iuc+ybt+bla_OXA-1+bla_OXA-48).Convergent XDR-hv-Kp detected has outbreak potential, warranting effective antimicrobial stewardship and infection control.

与医院获得性感染相关的肺炎克雷伯菌(Kp) 具有广泛耐药性 (XDR)，给治疗带来了问题。了解 XDR -Kp 的遗传流行病学可以确定其通过铁载体的存在而具有高毒力 (hv) 的潜力。 我们对从印度一家医疗机构的 14 名复杂尿路感染患者中分离出的18 种粘菌素耐药性 XDR-Kp 的基因组进行了分析。18 个生物体包含 ST：ST14 (9/18)、ST147 (5/18)、ST231 (2/18)、ST2096 (1/18) 和 ST25 (1/18)。一个病房内多名患者感染同一种ST，具有共同的传染源。一些患者反复感染该病房内循环的多种 ST，这为医院传播提供了证据。β-内酰胺酶基因（bla _CTX-M-1、bla _SHV和bla _ampH）存在于所有分离株中。bla _NDM-1存在于分离株 15/18 中，bla _OXA-1存在于分离株 16/18 中，bla _TEM-1D存在于分离株 13/18 中，bla _OXA-48存在于分离株 14,19 和 30 中. 用各种 IS 元件破坏mgrB是 6 个分离株产生粘菌素耐药性的原因。这些分离株中最常见的 K 型是 K2 (10/18)。一种 XDR 聚合 hv-Kp ST2096 与延长住院时间相关（iuc+ybt+bla _OXA-1 +bla _OXA-48）。检测到的聚合 XDR-hv-Kp 具有爆发潜力，需要有效的抗菌管理和感染控制。