Photo-responsive combinational therapeutics attained significant attention in cancer theranostic owing to the versatile features of nanomaterials. The simplest nano-design with unique properties to carry out multifunctionalties is a challenging assignment. Herein, a facile solvothermal method is employed to fabricate homogeneous MnO₂ sea urchin-shaped nanoparticles (MnO₂-OVA NPs) with a high loading capacity (86.15%) of ovalbumin (OVA) antigen. The prepared MnO₂-OVA NPs demonstrated excellent biocompatibility against different cell lines and significant cellular uptake, resulting in mature dendritic cells to enhance anti-tumor immunity. The synthesized sea urchin-shaped MnO₂-OVA NPs further exhibited self-generated catalytic properties that efficiently relieve tumor hypoxia and improve cancer therapies. More excitingly, MnO₂-OVA NPs endorsed reactive oxygen species (ROS) in response of minute UV irradiation (mW) for photodynamic therapy. Further, the prepared photo-responsive nanoparticles showed promising T₁-MR imaging and relaxivity properties for diagnosis and real-time drug delivery monitoring. These synergetic therapeutic strategies produced by MnO₂-OVA NPs showed excellency as a potential theranostic agent.

中文翻译：

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用于增强 T1 磁共振成像和癌症免疫治疗的光响应卵清蛋白 MnO2 纳米颗粒

由于纳米材料的多功能特性，光响应组合疗法在癌症治疗诊断中获得了极大的关注。最简单的纳米设计具有独特的性能来实现多功能性是一项具有挑战性的任务。在此，采用简便的溶剂热法制备具有高卵清蛋白（OVA）抗原负载量（86.15%）的均质MnO ₂海胆形纳米颗粒（MnO _{2 -OVA NPs）。}制备的MnO ₂ -OVA NPs对不同细胞系表现出优异的生物相容性和显着的细胞摄取，导致成熟的树突状细胞增强抗肿瘤免疫力。合成的海胆状MnO ₂ -OVA NPs进一步表现出自生催化特性，可有效缓解肿瘤缺氧并改善癌症治疗。更令人兴奋的是，MnO ₂ -OVA NPs 支持活性氧（ROS）响应微小的紫外线照射（mW）进行光动力疗法。此外，制备的光响应纳米颗粒显示出用于诊断和实时药物输送监测的有前景的T _{1 -MR成像和弛豫特性。MnO 2} -OVA NPs产生的这些协同治疗策略显示出作为潜在治疗诊断剂的卓越性能。